Effects of Preoperative Sleep Disorders on Anesthesia Recovery and Postoperative Pain in Patients Undergoing Laparoscopic Gynecological Surgery under General Anesthesia

doi:10.1155/2022/7998104

科研成果详情

题名	Effects of Preoperative Sleep Disorders on Anesthesia Recovery and Postoperative Pain in Patients Undergoing Laparoscopic Gynecological Surgery under General Anesthesia
作者	Yu, Sicong1,2; Xiong, Yicheng 3; Lu, Guangtao 2; Xiong, Xiangqing1
发表日期	2022-12-15
发表期刊	MEDIATORS OF INFLAMMATION 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	INFLAMMATORY MARKERS ; CYTOKINES ; COGNITION ; INSOMNIA ; QUALITY
摘要	Sleep disorder dramatically affects people's physical and mental health. Here, we investigated the effect of preoperative sleep disorders on anesthesia recovery and postoperative pain in patients undergoing laparoscopic gynecological surgery under general anesthesia. 120 patients who underwent elective laparoscopic gynecological surgery under general anesthesia in Taizhou Central Hospital from November 2021 to March 2022 were included. According to the score of the Pittsburgh sleep quality index (PSQI), the participating patients were divided into four groups: control group (control group), mild sleep disorder group A (group A), moderate sleep disorder group B (group B), and severe sleep disorder group C (group C), with 30 patients in each group. The changes of mean arterial pressure (MAP) and heart rate (HR) at different time points, operation time, anesthesia time, extubation time, the time when Aldrete score reached 10 points, visual analog score (VAS) serum interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) were compared among different groups. Our study demonstrated that there were no significant differences in MAP and HR among the four groups at the same time points (all P > 0.05). Significant differences in the time of extubation and Aldrete score reaching 10 points had been found among the four groups (all P < 0.001), indicating more sleep disorder induced longer extubation and recovery time. There were significant differences in VAS scores among the four groups at both different and the same time points (all P < 0.001), suggesting more sleep disorders induced more pain in the sufferers. Serum IL-6 levels were significantly higher in the three sleep disorder groups than the control group at 6 h and 24 h after the operation (all P < 0.05), while group C has the highest IL-6 levels as compared to the other group (P = 0.09 and P < 0.001, respectively). At 6 h after operation, serum levels of TNF-alpha in group C were significantly higher than in the control group (P = 0.044), but no significant differences were found in the other two groups (all P > 0.05). Positive correlation with preoperative PSQI score has been found with the times of extubation, the time of Aldrete score reaching 10 points, the VAS at 1 h, 6 h, and 24 h after operation, the level of serum IL-6 at 1 day before operation and 6 h and 24 h after operation, and the TNF-alpha at 6 h and 24 h after operation (all P < 0.001). The present study showed that the degree of preoperative sleep disorders could affect the quality of postoperative awakening and pain of patients undergoing laparoscopic gynecological surgery under general anesthesia, which might be associated with the aggravation of inflammatory reactions in the body.
资助项目	Science and Technology Foundation of Wenzhou, Zhejiang Province, China [Y20211139]; National Health Commission Scientific Research Fund, Zhejiang, China [WKJ-ZJ-2131]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	0962-9351
EISSN	1466-1861
卷号	2022
DOI	10.1155/2022/7998104
页数	8
WOS类目	Cell Biology ; Immunology
WOS研究方向	Cell Biology ; Immunology
WOS记录号	WOS:000903796900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	36570021
SCOPUSEID	2-s2.0-85144637545
通讯作者地址	[Xiong, Xiangqing]Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Immunology;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172168
专题	附属第一医院阿尔伯塔学院
通讯作者	Xiong, Xiangqing
作者单位	1.Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Anesthesiology,Taizhou Central Hospital (Taizhou University Hospital),Taizhou,China; 3.Alberta Institute,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 麻醉科
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 麻醉科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yu, Sicong,Xiong, Yicheng,Lu, Guangtao,et al. Effects of Preoperative Sleep Disorders on Anesthesia Recovery and Postoperative Pain in Patients Undergoing Laparoscopic Gynecological Surgery under General Anesthesia[J]. MEDIATORS OF INFLAMMATION,2022,2022.
APA	Yu, Sicong, Xiong, Yicheng, Lu, Guangtao, & Xiong, Xiangqing. (2022). Effects of Preoperative Sleep Disorders on Anesthesia Recovery and Postoperative Pain in Patients Undergoing Laparoscopic Gynecological Surgery under General Anesthesia. MEDIATORS OF INFLAMMATION, 2022.
MLA	Yu, Sicong,et al."Effects of Preoperative Sleep Disorders on Anesthesia Recovery and Postoperative Pain in Patients Undergoing Laparoscopic Gynecological Surgery under General Anesthesia".MEDIATORS OF INFLAMMATION 2022(2022).