Modification of Vancomycin Dosing in Cardiac Surgery With Cardiopulmonary Bypass

doi:10.1002/jcph.2190

科研成果详情

题名	Modification of Vancomycin Dosing in Cardiac Surgery With Cardiopulmonary Bypass
作者	Wang, Lei1; Yu, Xu-ben2,3,4; Zhou, Zi-Ye2; Wang, Jue1; Zheng, Liu-Pu1; Dai, Ying2; Wang, Yu-Zhen 3; Zhang, Xiao-Shan3; Chen, Chuang3; Shi, Da-Wei2; Zhang, Chun-Hong 2
发表日期	2023-04
发表期刊	JOURNAL OF CLINICAL PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access ; Journal Article
关键词	cardiac surgery cardiopulmonary bypass dosing regimen surgical-site infections vancomycin surgical site infections
其他关键词	ANTIBIOTIC-PROPHYLAXIS ; PHARMACOKINETICS ; GUIDELINE ; SOCIETY ; RISK
摘要	This study aims to assess the risk factors for insufficient vancomycin concentrations for its prophylactic use in adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) and to modify the dosing regimen to achieve appropriate plasma concentrations. A total of 27 patients with vancomycin dosing of 1 to 1.5 g based on a weight cutoff of 67 kg were included, of which only 13 (48.15%) had vancomycin plasma concentration >15 mg/L at surgical closure. Risk factors of vancomycin concentration <15 mg/L at surgical-site closure were confirmed by multivariate logistic regression analysis, which showed that CPB duration was an independent predictor. Patients with CPB duration >4 hours had significantly lower vancomycin concentrations and lower proportion in achieving target vancomycin concentration at the end of CPB and surgical closure. For patients with CPB >4 hours, the modified dosing regimen that a second dose of 0.5 to 0.75 g added at 4 hours since the onset of CPB improved the target achievement of vancomycin concentration at surgical closure. Taken together, CPB duration >4 hours was the risk factor for insufficient vancomycin concentration at surgical closure, while our modified dosing could improve the vancomycin concentrations for its prophylactic use in patients undergoing cardiac surgery with CPB.
资助项目	Natural Science Foundation of Zhejiang Province [LQ20H310003]
出版者	WILEY
出版地	HOBOKEN
ISSN	0091-2700
EISSN	1552-4604
卷号	63 期号:4 页码:490-497
DOI	10.1002/jcph.2190
页数	8
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000916093700001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-01
URL	查看原文
PubMed ID	36458612
SCOPUSEID	2-s2.0-85146958257
通讯作者地址	[Zhang, Chun-Hong]Department of Pharmacy,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/172150
专题	附属第一医院药学院（分析测试中心）_药学系附属第一医院_药学部药学部
通讯作者	Zhang, Chun-Hong
作者单位	1.Division of Cardiac Surgery,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Pharmacy,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Pharmacy,Wenzhou Medical University,Wenzhou,China; 4.Department of Pharmacology,Chonnam National University,Gwangju,South Korea
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Lei,Yu, Xu-ben,Zhou, Zi-Ye,et al. Modification of Vancomycin Dosing in Cardiac Surgery With Cardiopulmonary Bypass[J]. JOURNAL OF CLINICAL PHARMACOLOGY,2023,63(4):490-497.
APA	Wang, Lei., Yu, Xu-ben., Zhou, Zi-Ye., Wang, Jue., Zheng, Liu-Pu., ... & Zhang, Chun-Hong. (2023). Modification of Vancomycin Dosing in Cardiac Surgery With Cardiopulmonary Bypass. JOURNAL OF CLINICAL PHARMACOLOGY, 63(4), 490-497.
MLA	Wang, Lei,et al."Modification of Vancomycin Dosing in Cardiac Surgery With Cardiopulmonary Bypass".JOURNAL OF CLINICAL PHARMACOLOGY 63.4(2023):490-497.