The spatial-temporal reactive changes of compressed optic nerve in a clinically relevant rabbit model of persistent compressive optic nerve axonopathy.

doi:10.1016/j.exer.2022.109343

科研成果详情

题名	The spatial-temporal reactive changes of compressed optic nerve in a clinically relevant rabbit model of persistent compressive optic nerve axonopathy.
作者	Wu, Ende; Jiang, XiaoHui; Sun, Jiaying; Xu, Boyue; Li, Wenzhe; Liao, Qianling; Zhang, Yikui; Zhou, Guangming; Wu, Wencan
发表日期	2023-01
发表期刊	Experimental eye research 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Research Support, Non-U.S. Gov't
关键词	Animal model Anterograde axonal transport Compressive optic nerve axonopathy Ganglion cell complex Optic nerve Rabbit
其他关键词	RETINAL GANGLION-CELLS ; SINUS MUCOCELE ; NEUROPATHY ; TRANSECTION ; REDUCTION ; LESION ; CRUSH
摘要	The optic nerve (ON) can get compressed in different diseases. However, the pathological and functional changes occurring in the compressed ON over time under constant compression are still unclear. In the present study, we implanted an artificial tube around the optic nerve of a rabbit to primarily create a clinically relevant persistent compressive optic nerve axonopathy (PCOA). Due to the protuberance on the inner ring of the tube, steady and persistent compressions were maintained. In this model, we investigated the thickness of ganglion cell complex (GCC), retinal ganglion cell (RGC) density, axon density of optic nerve, flash visual evoked potential (FVEP), and anterograde axonal transport at various times in four different groups viz. the no comp, 1/2 comp, 3/4 comp, and crush groups. The GCC thickness, RGC density, and axon density of ON were hierarchically and significantly decreased in 1/2 comp, 3/4 comp, and crush groups. Compared to no comp eyes, the P2 amplitude ratio of FVEP was significantly decreased in 3/4 comp but not in 1/2 comp eyes. Only a portion of the optic nerve lost the ability of anterograde axonal transport in the 1/2 comp group. However, it was evident at 2-wpo and more prominent at 4-wpo in 3/4 comp eyes. This study reveals that the compression only induces the homolateral ON axons impairment and the proportion of the affected axons maintains the same for mild compression for at least three months. Furthermore, an underlying threshold effect highlights that mild compression does not require urgent surgery, while the severe compression warrants immediate surgical intervention.
资助项目	Zhejiang Provincial Natural Science Foundation of China [LQ20H120003]; Innovation Research Project of the Eye Hospital of Wenzhou Medical University [YNCX201603]; National Key R & D Program of China [2021YFA1101200]; Key R & D Program of Zhejiang Province [2019C03009]
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
ISSN	0014-4835
EISSN	1096-0007
卷号	226 页码:109343
DOI	10.1016/j.exer.2022.109343
页数	8
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:000953934000001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2022-12
URL	查看原文
PubMed ID	36509163
SCOPUSEID	2-s2.0-85144021399
通讯作者地址	[Wu, Ende]School of Optometry and Ophthalmology and Eye Hospital,Wenzhou Medical University,270 Xueyuan Road, Zhejiang,Wenzhou,325027,China ; [Wu, Wencan]School of Optometry and Ophthalmology and Eye Hospital,Wenzhou Medical University,270 Xueyuan Road, Zhejiang,Wenzhou,325027,China
Scopus学科分类	Ophthalmology;Sensory Systems;Cellular and Molecular Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/171572
专题	眼视光学院（生物医学工程学院）、附属眼视光医院眼视光学院（生物医学工程学院）、附属眼视光医院_眼鼻相关及眼眶眼肿瘤专科
通讯作者	Wu, Ende; Wu, Wencan
作者单位	The Eye Hospital,School of Ophthalmology & Optometry,Wenzhou Medical University,Wenzhou,325027,China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Wu, Ende,Jiang, XiaoHui,Sun, Jiaying,et al. The spatial-temporal reactive changes of compressed optic nerve in a clinically relevant rabbit model of persistent compressive optic nerve axonopathy.[J]. Experimental eye research,2023,226:109343.
APA	Wu, Ende., Jiang, XiaoHui., Sun, Jiaying., Xu, Boyue., Li, Wenzhe., ... & Wu, Wencan. (2023). The spatial-temporal reactive changes of compressed optic nerve in a clinically relevant rabbit model of persistent compressive optic nerve axonopathy.. Experimental eye research, 226, 109343.
MLA	Wu, Ende,et al."The spatial-temporal reactive changes of compressed optic nerve in a clinically relevant rabbit model of persistent compressive optic nerve axonopathy.".Experimental eye research 226(2023):109343.