Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.

doi:10.1016/j.intimp.2022.109398

科研成果详情

题名	Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.
作者	Liu, Li 1; Shi, Qiangqiang 2; Wang, Kankai3; Qian, Yao1; Zhou, Liqin 1; Bellusci, Saverio 4; Chen, Chengshui1,5; Dong, Nian 1
发表日期	2022-12
发表期刊	International immunopharmacology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Fibroblast growth factor 10 Lung injury Oxidative stress Particulate matter Pyroptosis
其他关键词	NLRP3 INFLAMMASOME ACTIVATION
摘要	Particulate matter (PM) is a major environmental contaminant that causes and worsens respiratory diseases. Fibroblast growth factor 10 (FGF10), a paracrine fibroblast growth factor that specifically stimulates repair and regeneration after injury, has been shown to protect against PM-induced lung injury. However, the underlying mechanisms are still unclear. In this study, the protective effects of FGF10 were investigated using a PM-induced lung injury mouse model in vivo and BEAS-2B cells in vitro. According to the findings, FGF10 treatment alleviated PM-induced oxidative damage and pyroptosis in vivo and in vitro. Mechanistically, FGF10 activated antioxidative Nrf2 signaling. Inhibition of PI3K signaling with LY294002 or Nrf2 signaling with ML385 revealed that FGF10-mediated lung protection was mediated by the PI3K/Akt/Nrf2 pathway. These results collectively indicate that FGF10 inhibits oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 pathway, suggesting a possible therapy for PM-induced lung injury.
资助项目	National Nature Science Foundation of China; Zhejiang Provincial Science Technology Department Foundation; Wenzhou Technology Foundation; [82170017]; [2022RC203]; [Y20220035]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	1567-5769
EISSN	1878-1705
卷号	113 期号:Pt A 页码:109398
DOI	10.1016/j.intimp.2022.109398
页数	12
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:000891847900007
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
Pubmed记录号	36461597
Scopus记录号	2-s2.0-85141297359
通讯作者地址	[Bellusci, Saverio]Department of Internal Medicine,Universities of Giessen and Marburg Lung Center (UGMLC),Cardio-Pulmonary Institute (CPI),Member of the German Center for Lung Research (DZL),Justus-Liebig University Giessen,Giessen,35392,Germany
scopus学科分类	Immunology and Allergy;Immunology;Pharmacology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/171501
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_老化与神经疾病重点实验室其他_附属东阳医院（东阳市人民医院）其他_温州医科大学附属衢州医院
通讯作者	Bellusci, Saverio
作者单位	1.Zhejiang Provincial Key Laboratory of Interventional Pulmonology,Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Respiratory Medicine,Affiliated Dongyang Hospital of Wenzhou Medical University,Jinhua,322100,China; 3.Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Department of Internal Medicine,Universities of Giessen and Marburg Lung Center (UGMLC),Cardio-Pulmonary Institute (CPI),Member of the German Center for Lung Research (DZL),Justus-Liebig University Giessen,Giessen,35392,Germany; 5.Department of Pulmonary and Critical Care Medicine,The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou,324000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Liu, Li,Shi, Qiangqiang,Wang, Kankai,et al. Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.[J]. International immunopharmacology,2022,113(Pt A):109398.
APA	Liu, Li., Shi, Qiangqiang., Wang, Kankai., Qian, Yao., Zhou, Liqin., ... & Dong, Nian. (2022). Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.. International immunopharmacology, 113(Pt A), 109398.
MLA	Liu, Li,et al."Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.".International immunopharmacology 113.Pt A(2022):109398.