The impact of COVID-19 on the clinical trial

doi:10.1371/journal.pone.0251410

科研成果详情

题名	The impact of COVID-19 on the clinical trial
作者	Chen, Zhimin 1; Chen, Liran 2; Chen, Huafang3
发表日期	2021-05-11
发表期刊	PLOS ONE 影响因子和分区
语种	英语
原始文献类型	Article
摘要	The objective of this study was to explore the impact of the coronavirus disease 2019 epidemic on ongoing and upcoming drug clinical trials. Qualitative semi-structured interviews were conducted with clinical trial staff and clinical trial subjects were surveyed by questionnaire in this study. The results of interviews and questionnaire showed that coronavirus disease 2019 pandemic has led to many changes in the implementation of drug clinical trials, including: a variety of meetings being held online webinars using various platforms, telemedicine and follow-up by video, A large number of deviations from protocol and losses of follow-up, delivery of clinical trial drugs by express, additional workload caused by screening for coronavirus, and anxiety of subjects. These results suggest that the coronavirus disease 2019 outbreak has hindered the progress and damaged the quality of clinical trials. The online meeting, remote follow-up, express delivery of drugs and remote monitoring in the epidemic environment can ensure the progress of clinical trials to a certain extent, but they cannot fully guarantee the quality as before.
出版者	PUBLIC LIBRARY SCIENCE
出版地	SAN FRANCISCO
ISSN	1932-6203
卷号	16 期号:5 页码:e0251410.
DOI	10.1371/journal.pone.0251410
页数	8
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000664626600036
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33974651
PMC记录号	PMC8112689
SCOPUSEID	2-s2.0-85105591080
通讯作者地址	[Chen, Zhimin]Ningbo Hosp Tradit Chinese Med, Ningbo, Zhejiang, Peoples R China.
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/17135
专题	附属第一医院_药物临床试验机构办公室
通讯作者	Chen, Zhimin
作者单位	1.Ningbo Hosp Tradit Chinese Med, Ningbo, Zhejiang, Peoples R China; 2.Tang Wealth Investment Management Co Ltd, Shanghai, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Off Drug Clin Trial Inst, Wenzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zhimin,Chen, Liran,Chen, Huafang. The impact of COVID-19 on the clinical trial[J]. PLOS ONE,2021,16(5):e0251410..
APA	Chen, Zhimin, Chen, Liran, & Chen, Huafang. (2021). The impact of COVID-19 on the clinical trial. PLOS ONE, 16(5), e0251410..
MLA	Chen, Zhimin,et al."The impact of COVID-19 on the clinical trial".PLOS ONE 16.5(2021):e0251410..