Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior

doi:10.1007/s11060-009-0107-y

科研成果详情

题名	Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior
作者	Wu, Zhe Bao 1; Zheng, Wei Ming 1; Su, Zhi Peng 1; Chen, Yong1; Wu, Jin Sen 1; Wang, Cheng De 1; Lin, Chen1; Zeng, Yan Jun 2; Zhuge, Qi Chuan 1
发表日期	2010-08
发表期刊	JOURNAL OF NEURO-ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Prolactinoma Dopamine 2 receptor isoforms Estrogen receptor isoforms Dopamine agonist Invasiveness
其他关键词	RECEPTOR MESSENGER-RNA ; DOPAMINE D2 RECEPTOR ; PITUITARY-ADENOMAS ; CAVERNOUS SINUS ; RESISTANT ; ESTROGEN ; ESTRADIOL ; RELEASE
摘要	Invasive prolactinomas are more likely to be resistant to drug therapy but the mechanism of this is still unknown. The objective of this study was to analyze the different expression of ERmRNA and D2RmRNA isoforms in prolactinomas responsive and resistant to dopamine agonist (DA), and to discuss the correlation of such gene expression with tumor biological behavior. A prospective study of 20 consecutive patients who harbored prolactinomas was designed. Patients were classified as responsive (14 cases) or resistant (six cases) according to their clinical and biochemical response to bromocriptine. Tumor tissue samples were examined by means of QRT-PCR analysis. Median D2SmRNA expression in responsive patients was about 2.5-fold that in resistant ones (13.5 +/- A 10.4 and 5.4 +/- A 2.4, respectively, P = 0.09). No significant difference was found between D2LmRNA expression levels (P = 0.77). However, there was a significant difference between D2S/D2LmRNA ratios for responsive and resistant tumors (P = 0.012). A significant difference was not found between these two groups in levels of ER alpha mRNA and ER beta mRNA expression (P = 0.20 and 0.06, respectively). D2SmRNA expression was significantly different for invasive and noninvasive tumors (6.2 +/- A 3.6 vs. 17.0 +/- A 11.2, respectively, P = 0.02). The D2S/D2L ratio is related to the responsiveness of prolactinomas to DA medication, in which D2SmRNA plays an important role. Lower expression of D2SmRNA in invasive tumor patients suggests that invasive prolactinomas may be more likely to be resistant to DA medication.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30800347]; Science and Technology Department of Zhejiang Province [2007C33028]; Health Bureau of Zhejiang Province [2007A138]; Wenzhou Science and Technology Bureau [H20070040]
出版者	SPRINGER
出版地	NEW YORK
ISSN	0167-594X
EISSN	1573-7373
卷号	99 期号:1 页码:25-32
DOI	10.1007/s11060-009-0107-y
页数	8
WOS类目	Oncology ; Clinical Neurology
WOS研究方向	Oncology ; Neurosciences & Neurology
WOS记录号	WOS:000279459400003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	20063113
SCOPUSEID	2-s2.0-77954385678
通讯作者地址	[Zhuge Q. C.]Department of Neurosurgery,First Affiliated Hospital,Wenzhou Medical College,China
Scopus学科分类	Oncology;Neurology;Neurology (clinical);Cancer Research
引用统计	被引频次：46[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16982
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_神经外科附属第一医院
作者单位	1.Department of Neurosurgery,First Affiliated Hospital,Wenzhou Medical College,China; 2.Biomedical Engineering Center,Biomechanics and Medical Information Institute,Beijing University of Technology,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wu, Zhe Bao,Zheng, Wei Ming,Su, Zhi Peng,et al. Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior[J]. JOURNAL OF NEURO-ONCOLOGY,2010,99(1):25-32.
APA	Wu, Zhe Bao., Zheng, Wei Ming., Su, Zhi Peng., Chen, Yong., Wu, Jin Sen., ... & Zhuge, Qi Chuan. (2010). Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior. JOURNAL OF NEURO-ONCOLOGY, 99(1), 25-32.
MLA	Wu, Zhe Bao,et al."Expression of D2RmRNA isoforms and ERmRNA isoforms in prolactinomas: correlation with the response to bromocriptine and with tumor biological behavior".JOURNAL OF NEURO-ONCOLOGY 99.1(2010):25-32.