Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells

doi:10.18632/aging.103751

科研成果详情

题名	Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells
作者	Shi, Changying 1; Yang, Jiamei 1; Hu, Longmiao 2; Liao, Boyi 1; Qiao, Liang 1; Shen, Weifeng 1; Xie, Feng 3; Zhu, Guoqing4
发表日期	2020-08-15
发表期刊	AGING-US 影响因子和分区
语种	英语
原始文献类型	Article
关键词	hepatocellular carcinoma cancer stem cells glycochenodeoxycholic acid STAT3 signaling pathway
其他关键词	POOR-PROGNOSIS ; CANCER ; LIVER ; CONTRIBUTES ; INHIBITION ; ACTIVATION ; INVASION
摘要	The poor prognosis of hepatocellular carcinoma (HCC) is primarily attributed to its high frequency of recurrence and resistance to chemotherapy. Epithelial-to-mesenchymal transition (EMT) and the acquisition of cancer stem cells (CSCs) are the fundamental drivers of chemoresistance in HCC. Glycochenodeoxycholic acid (GCDC), a component of bile acid (BA), has been reported to induce necrosis in primary human hepatocytes. In the present work, we investigated the function of GCDC in HCC chemoresistance. We found that GCDC promoted chemoresistance in HCC cells by down-regulating and up-regulating the expression of apoptotic and antiapoptotic genes, respectively. Furthermore, GCDC induced the EMT phenotype and stemness in HCC cells and activated the STAT3 signaling pathway. These findings reveal that GCDC promotes chemoresistance in HCC by inducing stemness via the STAT3 pathway and could be a potential target in HCC chemotherapy.
资助项目	Natural Science Foundation of ShanghaiNatural Science Foundation of Shanghai [16ZR1449200]
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1945-4589
卷号	12 期号:15 页码:15546-15555
DOI	10.18632/aging.103751
页数	10
WOS类目	Cell Biology ; Geriatrics & Gerontology
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
WOS记录号	WOS:000567901800006
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32756004
PMC记录号	PMC7467378
SCOPUSEID	2-s2.0-85089774881
通讯作者地址	[Zhu, Guoqing]Department of Interventional Radiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Yang, Jiamei]Department of Hepatology,Eastern Hepatobiliary Surgery Hospital,Affiliated to Second Military Medical University,Shanghai,China ; [Xie, Feng]Department of Biliary Surgery,Eastern Hepatobiliary Surgery Hospital,Affiliated to Second Military Medical University,Shanghai,China
Scopus学科分类	Aging;Cell Biology
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16879
专题	附属第一医院_介入科
通讯作者	Yang, Jiamei; Xie, Feng; Zhu, Guoqing
作者单位	1.Department of Hepatology,Eastern Hepatobiliary Surgery Hospital,Affiliated to Second Military Medical University,Shanghai,China; 2.National Center for Liver Cancer,Second Military Medical University,Shanghai,China; 3.Department of Biliary Surgery,Eastern Hepatobiliary Surgery Hospital,Affiliated to Second Military Medical University,Shanghai,China; 4.Department of Interventional Radiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Shi, Changying,Yang, Jiamei,Hu, Longmiao,et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. AGING-US,2020,12(15):15546-15555.
APA	Shi, Changying., Yang, Jiamei., Hu, Longmiao., Liao, Boyi., Qiao, Liang., ... & Zhu, Guoqing. (2020). Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells. AGING-US, 12(15), 15546-15555.
MLA	Shi, Changying,et al."Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells".AGING-US 12.15(2020):15546-15555.