Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities

doi:10.1021/acs.jafc.0c06332

科研成果详情

题名	Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities
作者	Liu, Jiaming1,2; Jin, Yangjie 3; Li, Haijun 4; Yu, Jiaheng 2; Gong, Tianyu 2; Gao, Xinxin 2; Sun, Jing 1
发表日期	2020-12-16
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	sepsis-associated encephalopathy Clostridium butyricum cognitive impairment neuroinflammation brain-derived neurotrophic factor
其他关键词	LACTOBACILLUS-HELVETICUS R0052 ; BIFIDOBACTERIUM-LONGUM R0175 ; MICROGLIA ; BEHAVIOR ; INJURY ; MICE ; ENCEPHALOPATHY ; DEFICITS ; MODEL
摘要	Recent evidence has revealed that probiotics could affect neurodevelopment and cognitive function via regulating gut microbiota. However, the role of probiotics in sepsis-associated encephalopathy (SAE) remained unclear. This study was conducted to assess the effects and therapeutic mechanisms of probiotic Clostridium butyricum (Cb) against SAE in mice. The SAE model mouse was induced by cecal ligation and puncture (CLP) and was given by intragastric administration with Cb for 1 month. A series of behavioral tests, including neurological severity score, tail suspension test, and elevated maze test, were used to assess cognitive impairment. Nissl staining and Fluoro-Jade C (FJC) staining were used to assess neuronal injury. Microglia activation, the release of neuroinflammatory cytokines, and the levels of ionized calcium-binding adapter molecule 1 (Iba-1) and brain-derived neurotrophic factor (BDNF) in the brain were determined. The compositions of the gut microbiota were detected by 16S rRNA sequencing. Our results revealed that Cb significantly attenuated cognitive impairment and neuronal damage. Moreover, Cb significantly inhibited excessive activation of microglia, decreased Iba-1 level, and increased BDNF level in the SAE mice. In addition, Cb improved gut microbiota dysbiosis of SAE mice. These findings revealed that Cb exerted anti-inflammatory effects and improved cognitive impairment in SAE mice, and their neuroprotective mechanisms might be mediated by regulating gut microbiota.
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	0021-8561
EISSN	1520-5118
卷号	68 期号:50 页码:14874-14883
DOI	10.1021/acs.jafc.0c06332
页数	69
WOS类目	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
WOS记录号	WOS:000600204700015
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20205209668091
EI主题词	Probiotics
URL	查看原文
PubMed ID	33284020
SCOPUSEID	2-s2.0-85097901451
通讯作者地址	[Sun, Jing]Department of Neurology,Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,Wenzhou, Zhejiang,325027,China
Scopus学科分类	Chemistry (all);Agricultural and Biological Sciences (all)
TOP期刊	TOP期刊
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16873
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院公共卫生学院_预防医学系
通讯作者	Sun, Jing
作者单位	1.Department of Neurology,Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,Wenzhou, Zhejiang,325027,China; 2.Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China; 3.Department of Emergency Medicine,Zhejiang Hospital,Hangzhou, Zhejiang,310013,China; 4.Department of Neurology,Taizhou Second People's Hospital,Taizhou, Zhejiang,317000,China
第一作者单位	附属第二医院; 公共卫生学院; 预防医学系
通讯作者单位	附属第二医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Liu, Jiaming,Jin, Yangjie,Li, Haijun,et al. Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(50):14874-14883.
APA	Liu, Jiaming., Jin, Yangjie., Li, Haijun., Yu, Jiaheng., Gong, Tianyu., ... & Sun, Jing. (2020). Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(50), 14874-14883.
MLA	Liu, Jiaming,et al."Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.50(2020):14874-14883.