题名 | Novel Action of 3,4-DAA ameliorating Acute Liver Allograft Injury |
作者 | |
发表日期 | 2012-08-17 |
会议录名称 | 2012年浙江省医学会肝病、感染病学学术年会暨浙江省感染科医师学术年会论文集 影响因子和分区 |
语种 | 英语 |
原始文献类型 | 中国会议 |
摘要 | The anti-allergic drug,N-(3,4-dimethoxycinnamonyl) anthranilic acid(3,4-DAA),is a synthetic anthranilic acid derivative that has been used therapeutically in Japan for many years.In this study,to investigate the effects of 3,4-DAA in allograft immunorejection model,liver orthotopic transplants were performed using inbred male Dark Agouti donors and Lewis rat recipients(allografts).The levels of indoleamine 2,3-dioxygenases (IDO) enzymic activities in four groups,allografts(control),DMSO-treated group(vehicle control),200 mg/kg/day 3,4-DAA-treated group and 200 mg/kg/day 3,4-DAA+5mg/ml 1-Methyl-D-tryptophan(1-MT)-treated group were confirmed by determination of L-kynurenine(L-Kyn) concentrations.The serum alanine aminotransferase(ALT) levels in 3,4-DAA-treated rats significantly decreased compared with those in mock and control group while treatment of 1-MT in allografts led to the opposite effect.Administration of 3,4-DAA reduced histological severity of allograft immunorejection,decreased serum levels of cytokines tumor necrosis factor-alpha(TNF-α) and interferon-gamma(IFN-γ),and raised serum levels of interleukin-10(IL-10), suggesting 3,4-DAA has both anti-inflammatory and anti-immunorejection properties through IDO in immune regulation,and may therefore be useful in filling an unmet need,in the treatment of allograft immunorejection. |
页码 | 2 |
收录类别 | CNKI |
文献类型 | 会议论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/167999 |
专题 | 其他_附属第三医院(瑞安市人民医院) |
作者单位 | 1.Department of Infectious Diseases 2.the Third Affiliated Hospital to Wenzhou Medical College 3.Department of infectious diseases 4.The First Affiliated Hospital to Medical College of Zhejiang University 5.Department of Surgery 6.The First Affiliated Hospital to Medical College of Zhejiang University |
推荐引用方式 GB/T 7714 | Qing-Feng Sun,Ji-Guang Ding,Ji-Fang Sheng,et al. Novel Action of 3,4-DAA ameliorating Acute Liver Allograft Injury[C],2012:2. |
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