Identification of lncRNAs associated with prognosis of rectum cancer by comprehensive bioinformatics analysis based on TCGA

doi:10.26914/c.cnkihy.2019.100448

科研成果详情

题名	Identification of lncRNAs associated with prognosis of rectum cancer by comprehensive bioinformatics analysis based on TCGA
作者	Guoping Yuan ; Junjie Chen ; Chengzu Wang
发表日期	2019-07-11
会议录名称	2019年浙江省医学会医学微生物与免疫学分会学术大会论文汇编影响因子和分区
语种	英语
原始文献类型	中国会议
摘要	Background:Although many advances have been made in the field of molecular biology,new approaches are still required to reveal the molecular mechanisms underlying the pathogenesis of rectal cancer and identify specific diagnostic and therapeutic targets.Methods:Here,we determined the expression profiles of lncRNA,mRNA,and microRNA(miRNA) in rectal cancer,and constructed the lncRNA-mRNA-miRNA ceRNA networks to identify the hub lncRNAs,mRNAs,and miRNAs in this cancer.Additionally,survival analysis was performed to identify survival-related genes.Results:69 DElncRNAs,32 DEmiRNAs,and 84 DEmRNAs were included in the ceRNA network.Based on the ceRNA principle,lncRNA ADAMTS9-AS2 was predicted to regulate the expression of FOXF2 gene through competitive binding to miR-182.The result of Log-rank test showed that three lncRNAs,five mRNAs,and one miRNA were associated with survival of rectum adenocarcinoma patients and multivariate Cox regression analysis identified four lncRNAs signature as a prognostic factor.Conclusions:These findings add to our understanding on the molecular mechanisms underlying the pathogenesis of rectal cancer and reveal potential diagnostic and therapeutic targets.
页码	2
DOI	10.26914/c.cnkihy.2019.100448
收录类别	CNKI
引用统计
文献类型	会议论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/167813
专题	其他_附属慈溪医院（慈溪市人民医院）
作者单位	1.Clinical laboratory 2.Cixi Affiliated Hospital of Wenzhou Medical University
推荐引用方式 GB/T 7714	Guoping Yuan,Junjie Chen,Chengzu Wang. Identification of lncRNAs associated with prognosis of rectum cancer by comprehensive bioinformatics analysis based on TCGA[C],2019:2.