The association between hyperuricemia and left atrial enlargement in healthy adults

doi:10.21037/atm-21-3402

科研成果详情

题名	The association between hyperuricemia and left atrial enlargement in healthy adults
作者	Fang, Danhong1,2,3; Wang, Na 3; Chen, Qinfen3; Wu, Gaojun2; Wu, Jiansheng3; Zhang, Wenbin 1; Fu, Guosheng 1
发表日期	2021-07
发表期刊	ANNALS OF TRANSLATIONAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Hyperuricemia (HU) uric acid left atrium atrial remodeling
其他关键词	ACTIVATED PROTEIN-KINASE ; SERUM URIC-ACID ; CELL-PROLIFERATION ; OXIDATIVE STRESS ; FIBRILLATION ; RISK ; INHIBITION ; GUIDELINES ; DIAGNOSIS
摘要	Background: Although hyperuricemia (HU) has been reported to be related to atrial fibrillation (AF), the relationship between HU and left atrial (LA) enlargement is unclear. The aim of this study was to investigate the interaction between HU and LA enlargement in healthy adults in China. Methods: This study retrospectively surveyed 5,392 people (3,336 males and 2,056 females) who underwent health checks. Basic data were obtained from all participants, including baseline characteristics and general health status through laboratory tests, echocardiography, and interviews. Multinomial logistic regression was used to analyze the experimental data and determine the association between HU and LA enlargement. In addition, the relationship between HU and LA enlargement in different gender groups was analyzed. Results: The prevalence of HU in this study was 20.3%. Compared with the normal LA group, the prevalence of HU in the LA enlargement group was significantly higher [31.5% vs. 18.1%; P<0.001; odds ratio (OR) =2.09, 95% confidence interval (CI): 1.78-2.45]. After adjustment for confounding variables, the interrelation of HU on LA enlargement was found to be independent in the total participants (OR =1.25, 95% CI: 1.04-1.51; P=0.017), especially in women (OR =1.73; 95% CI: 1.10-2.74; P=0.019) but not in men (P=0.195). Conclusions: HU is independently associated with LA enlargement in healthy adults, especially in women.
资助项目	Wenzhou Municipal Sci-Tech Bureau's program [Y2020315]
出版者	AME PUBL CO
出版地	SHATIN
ISSN	2305-5839
EISSN	2305-5847
卷号	9 期号:14 页码:1176
DOI	10.21037/atm-21-3402
页数	8
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000685280900008
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	34430617
PMC记录号	PMC8350625
通讯作者地址	[Fu, Guosheng]Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Cardiol, Hangzhou 310016, Peoples R China.
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16749
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_医疗保健中心
通讯作者	Fu, Guosheng
作者单位	1.Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Cardiol, Hangzhou 310016, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Cardiol, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Med & Hlth Care Ctr, Wenzhou, Peoples R China
第一作者单位	附属第一医院
推荐引用方式 GB/T 7714	Fang, Danhong,Wang, Na,Chen, Qinfen,et al. The association between hyperuricemia and left atrial enlargement in healthy adults[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9(14):1176.
APA	Fang, Danhong., Wang, Na., Chen, Qinfen., Wu, Gaojun., Wu, Jiansheng., ... & Fu, Guosheng. (2021). The association between hyperuricemia and left atrial enlargement in healthy adults. ANNALS OF TRANSLATIONAL MEDICINE, 9(14), 1176.
MLA	Fang, Danhong,et al."The association between hyperuricemia and left atrial enlargement in healthy adults".ANNALS OF TRANSLATIONAL MEDICINE 9.14(2021):1176.