Update Advances in Ribosome-associated Quality Control and Ribophagy br

doi:10.16476/j.pibb.2021.0270

科研成果详情

题名	Update Advances in Ribosome-associated Quality Control and Ribophagy br
其他题名	Update Advances in Ribosome-associated Quality Control and Ribophagy
作者	Zheng, Li-Yu 1,2; Yao, Ren-Qi 1,3; Yao, Yong-Ming 1
发表日期	2022-09
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 影响因子和分区
语种	英语
原始文献类型	Review
关键词	ribosome-associated quality control ribophagy protein homeostasis
其他关键词	E3 UBIQUITIN LIGASE ; SELECTIVE AUTOPHAGY ; STARVATION ; DEGRADATION ; PATHWAY ; RNA
摘要	The intracellular protein constantly remains in the dynamic process of synthesis and degradation,andits homeostasis appears to be closely related to the cellular function.A variety of protein quality control(PQC)mechanisms exist to monitor abnormalities occurred during protein synthesis and degradation,thereby ensuringproteome integrity and cellular fitness.The ribosome is the most abundant organelle in cells,and it is the majorsite for protein synthesis,for which each stage from biosynthesis to degradation is tightly controlled by variousquality control mechanisms.Ribosome-associated quality control(RQC)and ribophagy are identified as twomajor ribosome-associated PQC mechanisms that synergistically involve in the maintenance of translationalfunction and protein homeostasis.Also,they represent key players in adjusting ribosome content and translationalactivity for the changing environment,in turn facilitating cell survival under stress conditions.The dysregulationof RQC and ribophagy malfunction can substantially alter cellular fate and render cell death,resulting in the onsetand development of various ribosomopathies,including congenital diseases,neurological diseases,and malignanttumors.Targeting ribosomal dysfunction by restoring effective ribosome-associated PQC may serve as potentialremedy in treating ribosomopathies.The current review focuses on ribosomal-associated PQC with in-depthdiscussion regarding to the key roles of these pathways for the maintenance of protein homeostasis as well as theirpotential effects on the development of various human diseases.
资助项目	The National Natural Science Foundation of China [82130062, 81730057]
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
出版地	BEIJING
ISSN	1000-3282
卷号	49 期号:9 页码:1648-1657
DOI	10.16476/j.pibb.2021.0270
页数	10
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000865980500004
收录类别	SCIE ; ISTIC ; SCOPUS ; 北大核心 ; SCI ; 万方
URL	查看原文
SCOPUSEID	2-s2.0-85153055568
通讯作者地址	[Yao, Yong-Ming]Chinese Peoples Liberat Army Gen Hosp, Translat Med Res Ctr, Med Innovat Res Div, Beijing 100853, Peoples R China.
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/167244
专题	附属第一医院_急诊科
通讯作者	Yao, Yong-Ming
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Translat Med Res Ctr, Med Innovat Res Div, Beijing 100853, Peoples R China; 2.Wenzhou Med Univ, Emergency Dept, Affiliated Hosp 1, Wenzhou 325015, Peoples R China; 3.Naval Med Univ, Dept Burn Surg, Changhai Hosp, Shanghai 200433, Peoples R China
第一作者单位	附属第一医院_急诊科
推荐引用方式 GB/T 7714	Zheng, Li-Yu,Yao, Ren-Qi,Yao, Yong-Ming. Update Advances in Ribosome-associated Quality Control and Ribophagy br[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2022,49(9):1648-1657.
APA	Zheng, Li-Yu, Yao, Ren-Qi, & Yao, Yong-Ming. (2022). Update Advances in Ribosome-associated Quality Control and Ribophagy br. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 49(9), 1648-1657.
MLA	Zheng, Li-Yu,et al."Update Advances in Ribosome-associated Quality Control and Ribophagy br".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 49.9(2022):1648-1657.