Is serum NSE a useful biomarker in multiple system atrophy?

doi:10.54029/2022iwn

科研成果详情

题名	Is serum NSE a useful biomarker in multiple system atrophy?
作者	Zhang, Qiaoqiao1; Jin, Long 2
发表日期	2022-09
发表期刊	NEUROLOGY ASIA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Multiple system atrophy neuron-specific enolase biomarker Unified System Atrophy Rating Scale
其他关键词	NEURON-SPECIFIC ENOLASE ; CEREBROSPINAL-FLUID ; PROGNOSTIC VALUE ; GAMMA-ENOLASE ; MARKER ; DIAGNOSIS ; SEVERITY ; SURVIVAL ; DISEASE ; S100B
摘要	Objective: Multiple system atrophy (MSA) is a rapidly progressive and devastating neurodegenerative disease with limited lifespan. Biomarkers in diagnosing and evaluating the prognosis of MSA is a rapidly developing field. Neuron-specific enolase (NSE) is a biomarker of neuronal damage applicable in many neurological disorders. This study aimed to determine the usefulness of serum NSE as biomarker of MSA. Methods: In this case-control study involving 50 patients with MSA, electrochemiluminescence assay was used to investigate whether serum NSE levels. The disease severity of patients was assessed by Unified System Atrophy Rating Scale (UMSARS part II). The correlation between NSE levels and clinical features in MSA patients was analyzed. Results: The NSE levels were higher in MSA patients (11.59 +/- 2.52 ng/mL) than the control group (11.30 +/- 2.73 ng/mL); however, the difference was not statistically significant (P=0.581). In addition, no statistically significant difference was detected in the NSE levels between the parkinsonian (MSA-P) and cerebellar subtypes (MSA-C). No distinct difference was also detected between males and females of MSA patients. Furthermore, no correlations were established between NSE levels and age, disease duration, and UMSARS II score. Conclusions: This study suggest that serum NSE is not a useful biomarker of MSA. Future studies should examine whether there is a role for CSF NSE in reflecting neuronal damage in MSA patients.
资助项目	Dongyang People?s Hospital; [17-303]
出版者	ASEAN NEUROLOGICAL ASSOC
出版地	KUALA LUMPUR
ISSN	1823-6138
卷号	27 期号:3 页码:695-700
DOI	10.54029/2022iwn
页数	6
WOS类目	Clinical Neurology
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000870301600016
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85139105168
通讯作者地址	[Zhang, Qiaoqiao]Department of Neurology,Affiliated Dongyang Hospital of Wenzhou Medical University,NO.60, Wuning W. Road, Zhejiang,Dongyang,322100,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/167211
专题	第二临床医学院、附属第二医院、育英儿童医院_神经病学药学院（分析测试中心）_药学系其他_附属东阳医院（东阳市人民医院）
通讯作者	Zhang, Qiaoqiao
作者单位	1.Department of Neurology,Affiliated Dongyang Hospital of Wenzhou Medical University,Zhejiang,Dongyang,China; 2.Department of Pharmacy,Affiliated Dongyang Hospital of Wenzhou Medical University,Zhejiang,Dongyang,China
第一作者单位	附属东阳医院（东阳市人民医院）
通讯作者单位	附属东阳医院（东阳市人民医院）
第一作者的第一单位	附属东阳医院（东阳市人民医院）
推荐引用方式 GB/T 7714	Zhang, Qiaoqiao,Jin, Long. Is serum NSE a useful biomarker in multiple system atrophy?[J]. NEUROLOGY ASIA,2022,27(3):695-700.
APA	Zhang, Qiaoqiao, & Jin, Long. (2022). Is serum NSE a useful biomarker in multiple system atrophy?. NEUROLOGY ASIA, 27(3), 695-700.
MLA	Zhang, Qiaoqiao,et al."Is serum NSE a useful biomarker in multiple system atrophy?".NEUROLOGY ASIA 27.3(2022):695-700.