Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging

doi:10.1186/1556-276X-8-170

科研成果详情

题名	Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
作者	Lin, Jing 1; Zhou, Zhijun 1; Li, Zhiming 2; Zhang, Chunlei 1; Wang, Xiansong 1; Wang, Kan 1; Gao, Guo 1; Huang, Peng 1; Cui, Daxiang 1
发表日期	2013-04-15
发表期刊	NANOSCALE RESEARCH LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Bovine serum albumin Gold nanocluster Gold nanoparticle Folic acid Cellular imaging
其他关键词	BOVINE SERUM-ALBUMIN ; CARBON DOTS ; NANOCRYSTALS ; SURFACE ; BIOSYNTHESIS ; RADIATION ; PROTEINS ; DESIGN ; SILVER
摘要	Biomimetic synthesis has become a promising green pathway to prepare nanomaterials. In this study, bovine serum albumin (BSA)-conjugated gold nanoclusters/nanoparticles were successfully synthesized in water at room temperature by a protein-directed, solution-phase, green synthetic method. The synthesized BSA-Au nanocomplexes have fluorescence emission (588 nm) of gold nanoclusters and surface plasmon resonance of gold nanoparticles. The BSA-Au nanocomplexes display non-cytotoxicity and excellent biocompatibility on MGC803 gastric cancer cells. After conjugation of folic acid molecules, the obtained BSA-Au nanocomplexes showed highly selective targeting for MGC803 cells and dual-modality dark-field and fluorescence imaging.
资助项目	National Key Basic Research Program (973 Project)National Basic Research Program of China [2010CB933901, 2011CB933100]; National 863 Hi-tech Project of China [F2007AA022004]; Important National Science & Technology Specific Projects [2009ZX10004-311]; National Natural Scientific Fund [81225010, 1101169, 31100717, 81272987, 51102258]; New Century Excellent Talent of Ministry of Education of China [NCET-08-0350]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY12H11011]
出版者	SPRINGEROPEN
出版地	LONDON
ISSN	1931-7573
EISSN	1556-276X
卷号	8 期号:1
DOI	10.1186/1556-276X-8-170
页数	35
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS研究方向	Science & Technology - Other Topics ; Materials Science ; Physics
WOS记录号	WOS:000318793600001
收录类别	SCIE ; EI ; SCOPUS
EI入藏号	20132416422758
EI主题词	Gold compounds
URL	查看原文
Pubmed记录号	23587362
Scopus记录号	2-s2.0-84878756124
通讯作者地址	[Cui, Daxiang]Key Laboratory for Thin Film and Microfabrication of Ministry of Education,Institute of Micro-Nano Science and Technology,Shanghai Jiao Tong University,800 Dongchuan Road,China
scopus学科分类	Materials Science (all);Condensed Matter Physics
引用统计	被引频次：61[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16717
专题	第一临床医学院（信息与工程学院）、附属第一医院_皮肤病与性病学附属第一医院_皮肤科
通讯作者	Cui, Daxiang
作者单位	1.Key Laboratory for Thin Film and Microfabrication of Ministry of Education,Institute of Micro-Nano Science and Technology,Shanghai Jiao Tong University,800 Dongchuan Road,China; 2.Institute of Dermatology and Department of Dermatology at No. 1 Hospital,Wenzhou Medical College,China
推荐引用方式 GB/T 7714	Lin, Jing,Zhou, Zhijun,Li, Zhiming,et al. Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging[J]. NANOSCALE RESEARCH LETTERS,2013,8(1).
APA	Lin, Jing., Zhou, Zhijun., Li, Zhiming., Zhang, Chunlei., Wang, Xiansong., ... & Cui, Daxiang. (2013). Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging. NANOSCALE RESEARCH LETTERS, 8(1).
MLA	Lin, Jing,et al."Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging".NANOSCALE RESEARCH LETTERS 8.1(2013).