Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma.

doi:10.1155/2022/5005747

科研成果详情

题名	Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma.
作者	Tang, Qin 1; Chen, Yue-Ming2; Shen, Mei-Mei 1; Dai, Wen 3; Liang, Hang 4; Liu, Jun-Nan 4; Gao, Jian 1
发表日期	2022-10-06
发表期刊	Journal of oncology 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	CANCER ; MICROENVIRONMENT
摘要	Hepatocellular carcinoma (HCC) is one of the leading malignant carcinomas. Despite the advancement in the treatment for HCC, such as precise hepatectomy, radiotherapy, transarterial therapies, chemotherapy, targeted treatments, and immunotherapy, the 5-year overall survival rate of HCC is extremely low. Hence, novel biomarkers are urgently needed for advancing the therapy and prognosis of HCC. Neurexophilin 4 (NXPH4) is a neuropeptide-like glycoprotein. The study is designed to investigate the function of NXPH4 in HCC through a comprehensive bioinformatics analysis. NXPH4 expression status and prognostic values were analyzed via multiple datasets, such as TCGA, GEO, and ICGC. The association between NXPH4 and immune cell infiltration was estimated by TIMER, TISIDB, and CIBERSORT. In vitro, we explored the biological function of NXPH4 in JHH7 and SNU182 cells through knocking down the expression of NXPH4 via siRNA. In general, NXPH4 was predominantly upregulated in HCC tumors, and increased NXPH4 expression predicted unfavorable prognosis. The gene enrichment analysis displayed that NXPH4 was related with metabolic pathways. NXPH4 expression was correlated with immune cell infiltration. NXPH4 knockdown significantly suppressed proliferation, migration, and invasion of JHH7 and SNU182 cells. This study suggested that the upregulation of NXPH4 is associated with adverse prognosis and immune cell infiltration in HCC. NXPH4 could be a novel biomarker of unfavorable prognosis and an underlying target for immunotherapy in HCC.
资助项目	National Natural Science Foundation of China; Basic Research and Frontier Exploration Project of Chongqing and Technology Commission; Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University; [82173359]; [cstc2018jcyjAX0181]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1687-8450
EISSN	1687-8469
卷号	2022 页码:5005747
DOI	10.1155/2022/5005747
页数	23
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000871321700002
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
Pubmed记录号	36245978
Scopus记录号	2-s2.0-85140022296
通讯作者地址	[Gao, Jian]Department of Gastroenterology,Second Affiliated Hospital,Chongqing Medical University,Chongqing,China
scopus学科分类	Oncology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/166919
专题	第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室附属第一医院
通讯作者	Gao, Jian
作者单位	1.Department of Gastroenterology,Second Affiliated Hospital,Chongqing Medical University,Chongqing,China; 2.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,First Affiliated Hospital of Wenzhou Medical University,Zhejiang,China; 3.Bashu Secondary School,Chongqing,China; 4.Chongqing Medical University,Chongqing,China
推荐引用方式 GB/T 7714	Tang, Qin,Chen, Yue-Ming,Shen, Mei-Mei,et al. Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma.[J]. Journal of oncology,2022,2022:5005747.
APA	Tang, Qin., Chen, Yue-Ming., Shen, Mei-Mei., Dai, Wen., Liang, Hang., ... & Gao, Jian. (2022). Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma.. Journal of oncology, 2022, 5005747.
MLA	Tang, Qin,et al."Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma.".Journal of oncology 2022(2022):5005747.