beta 3-tubulin is a good predictor of sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer

doi:10.1007/s10238-015-0371-4

科研成果详情

题名	beta 3-tubulin is a good predictor of sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer
作者	Xiang, Youqun1; Yang, Yinlong 2,3; Guo, Guilong1; Hu, Xiaoqu1; Zhang, Huxiang4; Zhang, Xiaohua 1; Pan, Yifei1
发表日期	2016-08
发表期刊	CLINICAL AND EXPERIMENTAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Breast cancer Taxane Tubulin Immunohistochemistry
其他关键词	III BETA-TUBULIN ; PACLITAXEL RESISTANCE ; ISOTYPE EXPRESSION ; CARCINOMA-CELLS ; DOXORUBICIN ; DOCETAXEL ; THERAPY ; MARKER ; ERCC1 ; TRIAL
摘要	The objective of this study was to explore the relationship between beta 3-tubulin expression and sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer patients. A total of 48 local advanced breast cancer patients that received taxane-containing neoadjuvant chemotherapy were studied. The levels of beta 3-tubulin expression were tested by immunohistochemistry before chemotherapy and at the end of cycles 2, 4 and 6. The correlation between the efficacy of the chemotherapy and beta 3-tubulin expression and changes in beta 3-tubulin expression over the course of chemotherapy was examined. beta 3-tubulin protein expression before chemotherapy was significantly and negatively correlated with the response rate. The overall response rate was 31.8 % in the high beta 3-tubulin expression group, whereas it was 84.6 % in the low beta 3-tubulin expression group. At the end of cycles 2, 4 and 6 during the treatment course, the average expression rates of beta 3-tubulin were showed an increasing trend with beta 3-tubulin expression level at the end of cycle 4 being significantly different from that before chemotherapy. Nine patients that had a low beta 3-tubulin expression level preneoadjuvant chemotherapy changed to a high beta 3-tubulin expression level postneoadjuvant chemotherapy, and they had lower response rate than patients with consistent low. In conclusion, beta 3-tubulin is a good predictor of chemosensitivity to taxane for breast cancer, and the change of its expression level during chemotherapy may be an important cause of secondary resistance to taxane. Detection of beta 3-tubulin expression before and throughout the chemotherapy will help with selection of the chemotherapy treatment plan.
资助项目	First Affiliated Hospital of Wenzhou Medical University Incubation Project [FHY2014046]
出版者	SPRINGER-VERLAG ITALIA SRL
出版地	MILAN
ISSN	1591-8890
EISSN	1591-9528
卷号	16 期号:3 页码:391-397
DOI	10.1007/s10238-015-0371-4
页数	7
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000380668500017
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26088183
SCOPUSEID	2-s2.0-84931384179
通讯作者地址	[Pan, Yifei]Department of Surgical Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16683
专题	附属第一医院_肿瘤外科基础医学院（机能实验教学中心）_病理学与病理生理学系
通讯作者	Pan, Yifei
作者单位	1.Department of Surgical Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Breast Surgery,Fudan University Shanghai Cancer Center,Shanghai,China; 3.Department of Oncology,Shanghai Medical College,Fudan University,Shanghai,200000,China; 4.Department of Pathology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 肿瘤外科
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 肿瘤外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xiang, Youqun,Yang, Yinlong,Guo, Guilong,et al. beta 3-tubulin is a good predictor of sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer[J]. CLINICAL AND EXPERIMENTAL MEDICINE,2016,16(3):391-397.
APA	Xiang, Youqun., Yang, Yinlong., Guo, Guilong., Hu, Xiaoqu., Zhang, Huxiang., ... & Pan, Yifei. (2016). beta 3-tubulin is a good predictor of sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer. CLINICAL AND EXPERIMENTAL MEDICINE, 16(3), 391-397.
MLA	Xiang, Youqun,et al."beta 3-tubulin is a good predictor of sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer".CLINICAL AND EXPERIMENTAL MEDICINE 16.3(2016):391-397.