Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression

doi:10.18632/oncotarget.10833

科研成果详情

题名	Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression
作者	Chen, Xiangjian1,2; Zhu, Hua 3; Wu, Xiaoli4; Xie, Xuemeng2; Huang, Guanli5; Xu, Xiaoqun 6; Li, Shi 7; Xing, Chungen 1
发表日期	2016-08-23
发表期刊	ONCOTARGET 影响因子和分区
语种	英语
原始文献类型	Article
关键词	CRC ceRNA qRT-PCR lncRNA CCK-8
其他关键词	HUMAN BREAST-CANCER ; E-CATENIN CTNNA1 ; ALPHA-CATENIN ; COLORECTAL-CANCER ; HEPATOCELLULAR-CARCINOMA ; GASTRIC-CANCER ; E-CADHERIN ; RNA ; SUPPRESSOR ; DISEASE
摘要	Accumulating evidence indicates that deregulation of cancer-associated pseudogene is involved in the pathogenesis of cancer. In the study, we demonstrated that pseudogene CTNNAP1, for the CTNNA1 gene, was dysregulated in colorectal cancer and the degree of dysregulation was remarkably associated with tumor node metastasis (TNM) stage (P<0.05). The mechanistic experiments revealed that pseudogene CTNNAP1 played a pivotal role in the regulation of its cognate gene CTNNA1 by competition for microRNA-141. Moreover, gain-of-function approaches showed that overexpression of CTNNAP1 or CTNNA1 significantly inhibited cell proliferation and tumor growth in vitro and in vivo by inducing G0/G1 cell cycle arrest. Our findings add a new regulatory circuit via competing endogenous RNA (ceRNA) cross-talk between pseudogene CTNNAP1 and its cognate gene CTNNA1, and provide new insights into potential diagnostic biomarker for monitoring human colorectal cancer.
资助项目	Natural Science Foundation of Zhejiang Province of ChinaNatural Science Foundation of Zhejiang Province [LY16H160048]; Wenzhou Science and Technology Bureau Project [Y20150050, Y20150029]
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1949-2553
EISSN	1949-2553
卷号	7 期号:34 页码:55518-55528
DOI	10.18632/oncotarget.10833
页数	11
WOS类目	Oncology ; Cell Biology
WOS研究方向	Oncology ; Cell Biology
WOS记录号	WOS:000385435000110
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	27487124
PMC记录号	PMC5342433
通讯作者地址	[Chen, Xiangjian;Xing, Chungen]Soochow Univ, Dept Gen Surg, Affiliated Hosp 2, Suzhou, Jiangsu, Peoples R China. ; [Chen, Xiangjian]Wenzhou Med Univ, Dept Gen Surg, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China.
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16681
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学附属第一医院附属第一医院_泌尿外科附属第一医院_消化内科附属第一医院_肿瘤外科
通讯作者	Chen, Xiangjian; Xing, Chungen
作者单位	1.Soochow Univ, Dept Gen Surg, Affiliated Hosp 2, Suzhou, Jiangsu, Peoples R China; 2.Wenzhou Med Univ, Dept Gen Surg, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Dept Surg Oncol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 6.Wenzhou Med Univ, Affiliated Hosp 1, Operating Room, Wenzhou, Zhejiang, Peoples R China; 7.Wenzhou Med Univ, Dept Urol, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Xiangjian,Zhu, Hua,Wu, Xiaoli,et al. Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression[J]. ONCOTARGET,2016,7(34):55518-55528.
APA	Chen, Xiangjian., Zhu, Hua., Wu, Xiaoli., Xie, Xuemeng., Huang, Guanli., ... & Xing, Chungen. (2016). Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression. ONCOTARGET, 7(34), 55518-55528.
MLA	Chen, Xiangjian,et al."Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression".ONCOTARGET 7.34(2016):55518-55528.