Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling.

doi:10.1002/ptr.7635

科研成果详情

题名	Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling.
作者	Yang, Na1,2; Zou, Chunpeng3; Luo, Wu 2; Xu, Diyun1,2; Wang, Mengyang1,4; Wang, Yi1; Wu, Gaojun2; Shan, Peiren2; Liang, Guang1,2,5
发表日期	2023-02
发表期刊	Phytotherapy research : PTR 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Sclareol angiotensin II cardiac remodeling inflammation mitogen-activated protein kinases
其他关键词	KAPPA-B ; HYPERTROPHY ; HEART ; INDUCTION ; PATHWAYS ; FIBROSIS ; SYSTEM ; CELLS ; BETA
摘要	Chronic inflammation plays an important role in hypertensive heart failure. Suppressing angiotensin II (Ang II)-induced cardiac inflammation may contribute to the treatment of hypertension-associated heart failure. Sclareol, a natural product initially isolated from the leaves and flowers of Salvia sclarea, possesses antiinflammatory and immune-regulation activity in various systems. However, its effect on Ang II-induced cardiac remodeling remains unknown. In this study, we have explored the potential effects of sclareol on Ang II-induced heart failure. In vivo experiments were conducted in mice with Ang II-pump infusion for 28 days. Sclareol administration at 5 mg·kg-1 ·d-1 significantly reduced the expression of myocardial injury markers. Sclareol also exerts protective effects against Ang II-induced cardiac dysfunction in mice which is associated with alleviated cardiac inflammation and fibrosis. Transcriptome analysis revealed that inhibition of the Ang II-activated mitogen-activated protein kinase (MAPK) pathway contributed to the protective effect of sclareol. Sclareol inhibits Ang II-activated MAPKs pathway to reduce inflammatory response in mouse hearts and cultured cardiomyocytes. Blockage of MAPKs in cardiomyocytes abolished the antiinflammatory effects of sclareol. In conclusion, we show that sclareol protects hearts against Ang II-induced injuries through inhibiting MAPK-mediated inflammation, indicating the potential use of sclareol in the prevention of hypertensive heart failure
资助项目	National Natural Science Foundation of China[82170373];National Natural Science Foundation of China[82000793];Wenzhou Science and Technology Key Project[2018ZY009];Zhejiang Provincial Key Scientific Project[2021C03041];
出版者	WILEY
出版地	HOBOKEN
ISSN	0951-418X
EISSN	1099-1573
卷号	37 期号:2 页码:578-591
DOI	10.1002/ptr.7635
页数	14
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000861912100001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2022-09
URL	查看原文
PubMed ID	36178264
SCOPUSEID	2-s2.0-85139040870
通讯作者地址	[Liang, Guang]Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China ; [Shan, Peiren]Department of Cardiology and Medical Research Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Pharmacology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/166793
专题	药学院（分析测试中心）附属第二医院附属第一医院第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Shan, Peiren; Liang, Guang
作者单位	1.Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Cardiology,the First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.Department of Ultrasonography,the Second Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.Key Laboratory of Natural Medicines of the Changbai Mountain,Ministry of Education,Yanbian University,Yanji,China; 5.School of Pharmaceutical Sciences,Hangzhou Medical College,Hangzhou,Zhejiang,China
第一作者单位	药学院（分析测试中心）; 附属第一医院
通讯作者单位	药学院（分析测试中心）; 附属第一医院
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Yang, Na,Zou, Chunpeng,Luo, Wu,et al. Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling.[J]. Phytotherapy research : PTR,2023,37(2):578-591.
APA	Yang, Na., Zou, Chunpeng., Luo, Wu., Xu, Diyun., Wang, Mengyang., ... & Liang, Guang. (2023). Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling.. Phytotherapy research : PTR, 37(2), 578-591.
MLA	Yang, Na,et al."Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling.".Phytotherapy research : PTR 37.2(2023):578-591.