Raw Pinelliae Rhizoma: examination of sedative and hypnotic effects in mice and chemical analysis.

doi:10.1007/s11325-022-02714-y

科研成果详情

题名	Raw Pinelliae Rhizoma: examination of sedative and hypnotic effects in mice and chemical analysis.
作者	Lin, Sisi1,2; Chen, Haipeng 2; Nie, Bo 3; Jiang, Chengrou4; Yang, Hui 5; Wang, Qinglai 6; Yuan, Zhengzhong1
发表日期	2023-06
发表期刊	Sleep & breathing = Schlaf & Atmung 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Hypnotics Liquid chromatography Locomotion Pinellia ternata Polysomnography Sedatives
其他关键词	L-ARGININE
摘要	Raw "Pinelliae Rhizoma" (RPR) is widely used in Chinese clinics to treat insomnia. This study investigated its underlying sedative and hypnotic mechanisms and main active components., A locomotor activity test was used to evaluate the sedative effects of RPR at three dosages (0.2 g/mL, 0.4 g/mL, and 0.8 g/mL) in mice. Polysomnography was used to assess its ability to improve sleep. Ultra-performance liquid chromatography/time of flight/mass spectrometry (UPLC-TOF-MS) analysis was used to identify the potential active components of RPR., Mice in the RPR groups were less active than mice in the vehicle group; this difference was greatest in the 0.8 g/mL RPR group. Compared with the vehicle, 0.8 g/mL RPR increased the duration of rapid eye movement (REM) sleep in the dark phase. In addition, the duration of wakefulness in the 0.8 g/mL RPR group decreased with increasing durations of nonrapid eye movement (NREM) and REM sleep. Compared with diazepam, 0.8 g/mL RPR increased REM sleep duration in both the light and dark phases and increased the number of transitions both from NREM sleep to REM sleep and from REM sleep to wakefulness. A total of 33 RPR constituents, including 15 alkaloids, were identified., The results preliminarily indicated that RPR exerts sedative and hypnotic effects in mice, mainly leading to improvements in REM sleep. These effects are possibly due to the alkaloid constituents of RPR.
资助项目	Outstanding Youth Fund Project for Chinese Medicine of Zhejiang Province, China [2011zq014]; First Affiliated Hospital of Wenzhou Medical University [FHY2019041]
出版者	SPRINGER HEIDELBERG
出版地	HEIDELBERG
ISSN	1520-9512
EISSN	1522-1709
卷号	27 期号:3 页码:1143-1153
DOI	10.1007/s11325-022-02714-y
页数	11
WOS类目	Clinical Neurology ; Respiratory System
WOS研究方向	Neurosciences & Neurology ; Respiratory System
WOS记录号	WOS:000860398000001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2022-09
URL	查看原文
PubMed ID	36166133
SCOPUSEID	2-s2.0-85139169443
通讯作者地址	[Yuan, Zhengzhong]Department of Traditional Chinese Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Wang, Qinglai]Wenzhou Traditional Chinese Medicine Hospital,Wenzhou,China
Scopus学科分类	Otorhinolaryngology;Neurology (clinical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/166769
专题	附属第一医院_中医科
通讯作者	Wang, Qinglai; Yuan, Zhengzhong
作者单位	1.Department of Traditional Chinese Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Zhejiang Chinese Medical University,Hangzhou,China; 3.Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,China; 4.Wenzhou Medical University,Wenzhou,China; 5.School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing,China; 6.Wenzhou Traditional Chinese Medicine Hospital,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Lin, Sisi,Chen, Haipeng,Nie, Bo,et al. Raw Pinelliae Rhizoma: examination of sedative and hypnotic effects in mice and chemical analysis.[J]. Sleep & breathing = Schlaf & Atmung,2023,27(3):1143-1153.
APA	Lin, Sisi., Chen, Haipeng., Nie, Bo., Jiang, Chengrou., Yang, Hui., ... & Yuan, Zhengzhong. (2023). Raw Pinelliae Rhizoma: examination of sedative and hypnotic effects in mice and chemical analysis.. Sleep & breathing = Schlaf & Atmung, 27(3), 1143-1153.
MLA	Lin, Sisi,et al."Raw Pinelliae Rhizoma: examination of sedative and hypnotic effects in mice and chemical analysis.".Sleep & breathing = Schlaf & Atmung 27.3(2023):1143-1153.