Pancancer landscape analysis of the thymosin family identified TMSB10 as a potential prognostic biomarker and immunotherapy target in glioma.

doi:10.1186/s12935-022-02698-5

科研成果详情

题名	Pancancer landscape analysis of the thymosin family identified TMSB10 as a potential prognostic biomarker and immunotherapy target in glioma.
作者	Xiong, Ye1,2,3; Qi, Yanhua 1,2; Pan, Ziwen 1,2; Wang, Shaobo 1,2; Li, Boyan 1,2; Feng, Bowen 1,2; Xue, Hao 1,2; Zhao, Rongrong 1,2; Li, Gang 1,2
发表日期	2022-09-26
发表期刊	Cancer cell international 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Glioma Immune checkpoint blockade Pancancer TMSB10 Tumor microenvironment
其他关键词	TUMOR ; METASTASIS ; GENE
摘要	Thymosin family genes (TMSs), biologically important peptides with diverse intracellular and extracellular functions, have been shown to promote the progression of multiple cancers. However, multiomics characterization of TMSs and their role in human cancer prognosis has not been systematically performed., We performed a comprehensive analysis of TMSs and thymosin β10 (TMSB10) using multiomics data from more than 10,000 tumor samples of 33 cancer types from The Cancer Genome Atlas (TCGA). We used single-sample gene set enrichment analysis (ssGSEA) and the gene set variation analysis (GSVA) algorithm to investigate the differences in tumor microenvironment (TME) cell infiltration and functional annotation for individual tumor samples, respectively. The role of TMSB10 in the malignant progression of glioma, the promotion of macrophage infiltration,and immunosuppressive polarization, and the combination drug efficacy were assessed via biological function assays., We comprehensively assessed genomic mutations, expression dysregulation, prognosis and immunotherapeutic response across 33 human cancer samples and showed that TMSB10 is specifically overexpressed in almost all types of cancer tissues. Further pan-cancer analysis showed that TMSB10 is closely related to the biological function, immune regulation and prognosis of glioma. Similar results were also found in several public glioma cohorts and our Qilu local cohort. Further integration with other biological experiments revealed the key roles of TMSB10 in the malignant progression of glioma, the promotion of macrophage infiltration and immunosuppressive polarization. We also identified multiple drugs targeting cells with high TMSB10 expression and validated that knockdown of TMSB10 improved the efficacy of selumetinib (a MEK1/2 inhibitor approved by the FDA for the treatment of neurofibromatosis-associated tumors) and anti-PD1 treatment in glioma., These results indicate that TMSB10 holds promise as a novel prognostic marker and therapeutic target, providing a theoretical basis for the development of more effective and targeted clinical treatment strategies for glioma patients.
资助项目	National Natural Science Foundation of China[81874083;82072776;82072775;81702468;81802966;81902540;641 81874082;81472353];Natural Science Foundation of Shandong Province[ZR2019BH057 ZR2020QH174 ZR2021LSW025];Jinan Science and Technology Bureau[2021GXRC029];Key clinical Research project of Clinical Research Center of Shandong University[2020SDUCRCA011];Taishan Pandeng Scholar Program of Shandong Province[tspd20210322];
出版者	BMC
出版地	LONDON
ISSN	1475-2867
EISSN	1475-2867
卷号	22 期号:1 页码:294
DOI	10.1186/s12935-022-02698-5
页数	22
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000859911400001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
Pubmed记录号	36163046
Scopus记录号	2-s2.0-85139260392
通讯作者地址	[Xue, Hao]Shandong Key Laboratory of Brain Function Remodeling,Shandong,Jinan,250012,China ; [Zhao, Rongrong]Shandong Key Laboratory of Brain Function Remodeling,Shandong,Jinan,250012,China ; [Li, Gang]Shandong Key Laboratory of Brain Function Remodeling,Shandong,Jinan,250012,China
scopus学科分类	Oncology;Genetics;Cancer Research
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/166764
专题	附属第一医院_神经外科
通讯作者	Xue, Hao; Zhao, Rongrong; Li, Gang
作者单位	1.Department of Neurosurgery,Qilu Hospital,Cheeloo College of Medicine,Institute of Brain and Brain-Inspired Science,Shandong University,Shandong,Jinan,250012,China; 2.Shandong Key Laboratory of Brain Function Remodeling,Shandong,Jinan,250012,China; 3.Department of Neurosurgery,The Frist Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou City,325000,China
第一作者单位	温州医科大学
推荐引用方式 GB/T 7714	Xiong, Ye,Qi, Yanhua,Pan, Ziwen,et al. Pancancer landscape analysis of the thymosin family identified TMSB10 as a potential prognostic biomarker and immunotherapy target in glioma.[J]. Cancer cell international,2022,22(1):294.
APA	Xiong, Ye., Qi, Yanhua., Pan, Ziwen., Wang, Shaobo., Li, Boyan., ... & Li, Gang. (2022). Pancancer landscape analysis of the thymosin family identified TMSB10 as a potential prognostic biomarker and immunotherapy target in glioma.. Cancer cell international, 22(1), 294.
MLA	Xiong, Ye,et al."Pancancer landscape analysis of the thymosin family identified TMSB10 as a potential prognostic biomarker and immunotherapy target in glioma.".Cancer cell international 22.1(2022):294.