Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.

doi:10.1002/ptr.7625

科研成果详情

题名	Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.
作者	Zhang, Haojie 1,2,3; Wu, Chenyu1,2,3; Yu, Dong-dong 4; Su, Haohan1,2,3; Chen, Yanlin 5; Ni, Wenfei1,2,3
发表日期	2023-02
发表期刊	Phytotherapy research : PTR 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	autophagy inflammation oxidative stress piperine pyroptosis spinal cord injury
其他关键词	NEUROLOGICAL CLASSIFICATION ; INTERNATIONAL STANDARDS ; RESTORATION ; ACTIVATION ; MANAGEMENT ; APOPTOSIS ; NEURONS ; TARGET ; REPAIR
摘要	Spinal cord injury (SCI) is a serious injury that can lead to irreversible motor dysfunction. Due to its complicated pathogenic mechanism, there are no effective drug treatments. Piperine, a natural active alkaloid extracted from black pepper, has been reported to influence neurogenesis and exert a neuroprotective effect in traumatic brain injury. The aim of this study was to investigate the therapeutic effect of piperine in an SCI model. SCI was induced in mice by clamping the spinal cord with a vascular clip for 1 min. Before SCI and every 2 days post-SCI, evaluations using the Basso mouse scale and inclined plane tests were performed. On day 28 after SCI, footprint analyses, and HE/Masson staining of tissues were performed. On a postoperative Day 3, the spinal cord was harvested to assess the levels of pyroptosis, reactive oxygen species (ROS), inflammation, and autophagy. Piperine enhanced functional recovery after SCI. Additionally, piperine reduced inflammation, oxidative stress, pyroptosis, and activated autophagy. However, the effects of piperine on functional recovery after SCI were reversed by autophagy inhibition. The study demonstrated that piperine facilitated functional recovery after SCI by inhibiting inflammatory, oxidative stress, and pyroptosis, mediated by the activation of autophagy.
资助项目	Natural Science Foundation of Zhejiang Province[Y21H060050];Wenzhou Municipal Science and Technology Bureau[Y20190078];Clinical Scientific Research Project of the Second Affiliated Hospital of Wenzhou Medical University[SAHoWMU-CR2017-08-106];
出版者	WILEY
出版地	HOBOKEN
ISSN	0951-418X
EISSN	1099-1573
卷号	37 期号:2 页码:438-451
DOI	10.1002/ptr.7625
页数	14
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000854618300001
收录类别	PUBMED ; SCIE ; SCOPUS
在线发表日期	2022-09
URL	查看原文
PubMed ID	36114802
SCOPUSEID	2-s2.0-85138176498
通讯作者地址	[Ni, Wenfei]Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,#109 Xueyuan Road, Zhejiang,Wenzhou,325027,China
Scopus学科分类	Pharmacology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/166652
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院_骨科重点学科实验室
通讯作者	Ni, Wenfei
作者单位	1.Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 2.The Second School of Medicine,Wenzhou Medical University,Wenzhou,China; 3.Key Laboratory of Orthopaedics of Zhejiang Province,Wenzhou Medical University,Wenzhou,China; 4.Department of Urology,Huzhou Central Hospital,Huzhou,China; 5.Spinal Surgery Department,The Central Hospital of Lishui City,Lishui,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 温州医科大学
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Zhang, Haojie,Wu, Chenyu,Yu, Dong-dong,et al. Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.[J]. Phytotherapy research : PTR,2023,37(2):438-451.
APA	Zhang, Haojie, Wu, Chenyu, Yu, Dong-dong, Su, Haohan, Chen, Yanlin, & Ni, Wenfei. (2023). Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.. Phytotherapy research : PTR, 37(2), 438-451.
MLA	Zhang, Haojie,et al."Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement.".Phytotherapy research : PTR 37.2(2023):438-451.