Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus.

doi:10.1002/mus.27719

科研成果详情

题名	Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus.
作者	He, Weilei 1; Pang, Chunyang2; Chen, Luowei 3; Zeng, Yaying 4; Gao, Lingfei2; Huang, Huanjie2; Zhang, Wanli2; Wang, Xun2; Deng, Binbin2
发表日期	2022-12
发表期刊	Muscle & nerve 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	diabetic peripheral neuropathy low T3 syndrome nerve conduction study severity type 2 diabetes mellitus
其他关键词	PREVALENCE ; HYPOTHYROIDISM
摘要	Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus. Diabetic patients often have thyroid dysfunction. The aim of this study was to investigate the association between low triiodothyronine (T3) syndrome and DPN in patients with type 2 diabetes mellitus (T2DM)., A retrospective review was performed of 928 patients with T2DM for whom data was available for clinical manifestations and nerve conduction studies (NCS), and of 134 non-diabetic controls. The composite Z scores of conduction velocity and amplitude were calculated. Low T3 syndrome was defined as T3 levels below the lower limit of the reference interval., Among the patients with T2DM, 632 (68.1%) had DPN, and a larger proportion of these patients presented with low T3 syndrome than patients without DPN. After adjusting for potential confounders, low T3 syndrome was independently associated with the occurrence of DPN (odds ratio [OR] = 2.049, 95% confidence interval [CI] 1.319-3.181, p = .001) and the severity of DPN (OR = 1.597, 95% CI 1.030-2.476, p = .036). Adding the criterion of low T3 syndrome improved the prognostic performance of the traditional model (age + gender + diabetic duration + glycated hemoglobin [HbA1c]) for predicting DPN., Low T3 syndrome is associated with a higher risk and increased severity of DPN in patients with T2DM. These findings suggest that low T3 syndrome could be a predictor for risk stratification in patients with T2DM.
资助项目	National Natural Science Foundation of China[81901273];Natural Science Foundation of Zhejiang Province[LQ21H090018];Natural Science Foundation of Zhejiang Province[LY19H090014];
出版者	WILEY
出版地	HOBOKEN
ISSN	0148-639X
EISSN	1097-4598
卷号	66 期号:6 页码:723-729
DOI	10.1002/mus.27719
页数	7
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000857239000001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	36089765
SCOPUSEID	2-s2.0-85139013893
通讯作者地址	[Deng, Binbin]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Physiology;Neurology (clinical);Cellular and Molecular Neuroscience;Physiology (medical)
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/166609
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Deng, Binbin
作者单位	1.Department of Nuclear Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Neurology,The Second Affiliated Hospital of Zhejiang University,Hangzhou,China; 4.Department of Psychiatry,Zhejiang Traditional Chinese Medical Hospital,Hangzhou,China
第一作者单位	附属第一医院
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	He, Weilei,Pang, Chunyang,Chen, Luowei,et al. Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus.[J]. Muscle & nerve,2022,66(6):723-729.
APA	He, Weilei., Pang, Chunyang., Chen, Luowei., Zeng, Yaying., Gao, Lingfei., ... & Deng, Binbin. (2022). Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus.. Muscle & nerve, 66(6), 723-729.
MLA	He, Weilei,et al."Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus.".Muscle & nerve 66.6(2022):723-729.