Kangfuxin promotes apoptosis of gastric cancer cells through activating ER-stress and autophagy

doi:10.3892/mmr.2017.7716

科研成果详情

题名	Kangfuxin promotes apoptosis of gastric cancer cells through activating ER-stress and autophagy
作者	Chen, Pian-Pian 1; Ma, Xiu-Ying 2; Lin, Qian1; Xu, He-Lin1; Shi, Ong-Xue 1; Zhang, Hong-Yu1; Xiao, Jian1; Geng, Fu-Neng 2; Zhao, Ying-Zheng1
发表日期	2017-12
发表期刊	MOLECULAR MEDICINE REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Kangfuxin SGC-7901 cells gastric cancer ER stress apoptosis autophagy
其他关键词	ENDOPLASMIC-RETICULUM STRESS ; TRADITIONAL CHINESE MEDICINE ; UNFOLDED PROTEIN RESPONSE ; HUMAN-MELANOMA CELLS ; PATHWAY ; DEATH ; INHIBITION ; INVOLVEMENT ; THERAPY ; MODELS
摘要	Gastric cancer is a leading cause of cancer-associated mortality worldwide. In studies on the mechanisms of antigastric cancer drugs, autophagy and endoplasmic reticulum (ER) stress have been demonstrated to serve an active role in gastric cancer. The organic extract of Periplaneta americana (also termed American Cockroach), which is named Kangfuxin (KFX) in China, has been used clinically as a traditional Chinese medicine against disorders, including stomach bleeding, gastric ulcers, tuberculosis, burns and trauma. However, the role of KFX and its mechanism in gastric cancer remains to be elucidated. The present study aimed to determine the effects of KFX in vitro against cultured the human carcinoma SGC-7901 cell line, and to explore the potential mechanism of the anticancer effects of KFX in gastric cancer. SGC-7901 cells were treated with different concentrations of KFX for varying amounts of time. As a result, KFX treatment decreased the ratio of apoptosis regulators Bcl-2/Bax, activated ER stress and induced significant apoptosis in SGC-7901 cells. Furthermore, KFX was able to restore the ER stress activation blocked by 4-phenylbutyrate. In addition, KFX activated autophagy in SGC-7901 cells. These results demonstrated that ER stress, autophagy and the apoptosis-inducing effects of KFX in SGC-7901 cells may achieve promising anticancer effects in numerous other types of cancer. In particular, ER stress may serve an essential role in KFX-induced anticancer effects on gastric carcinoma and a secondary role in autophagy.
资助项目	Good Doctor Pharmaceutical Group [KJHX1505]; Ministry of Education of ChinaMinistry of Education, China [20133321120005]; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents; 151 Talent Project of Zhejiang province; 551 Talent Project of Wenzhou; Key Support of High Level Talent Innovation and Technology Project of Wenzhou; Zhejiang Provincial Foundation for Health Department [2015ZDA023, 2016KYA136]; Wenzhou Bureau of Science and Technology [Y2014730]; School Talent Start Fund of Wenzhou Medical University [QTJ15020]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1791-2997
EISSN	1791-3004
卷号	16 期号:6 页码:9043-9050
DOI	10.3892/mmr.2017.7716
页数	8
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000418229200152
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28990095
SCOPUSEID	2-s2.0-85032738327
通讯作者地址	[Zhao, Ying-Zheng]School of Pharmaceutical Sciences,Wenzhou Medical University,129 Gaojiaoyuan Street,Wenzhou, Zhejiang,325035,China
Scopus学科分类	Biochemistry;Molecular Medicine;Molecular Biology;Genetics;Oncology;Cancer Research
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16581
专题	药学院（分析测试中心）研究生工作部（研究生院）
通讯作者	Zhao, Ying-Zheng
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,129 Gaojiaoyuan Street,Wenzhou, Zhejiang,325035,China; 2.Sichuan Key Laboratory of Medical American Cockroach,88 Yingmenlukou Street,Chengdu, Sichuan,610000,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Chen, Pian-Pian,Ma, Xiu-Ying,Lin, Qian,et al. Kangfuxin promotes apoptosis of gastric cancer cells through activating ER-stress and autophagy[J]. MOLECULAR MEDICINE REPORTS,2017,16(6):9043-9050.
APA	Chen, Pian-Pian., Ma, Xiu-Ying., Lin, Qian., Xu, He-Lin., Shi, Ong-Xue., ... & Zhao, Ying-Zheng. (2017). Kangfuxin promotes apoptosis of gastric cancer cells through activating ER-stress and autophagy. MOLECULAR MEDICINE REPORTS, 16(6), 9043-9050.
MLA	Chen, Pian-Pian,et al."Kangfuxin promotes apoptosis of gastric cancer cells through activating ER-stress and autophagy".MOLECULAR MEDICINE REPORTS 16.6(2017):9043-9050.