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TitleTHE VALUE OF ADA LEVEL AND MONOCYTE RATIO IN PLEURAL EFFUSION TO DIFFERENTIATE TUBERCULOUS PLEURISY FROM MALIGNANT EFFUSION AND EMPYEMA
Creator
Date Issued2022
Source PublicationACTA MEDICA MEDITERRANEA   Impact Factor & Quartile
language英语
Original Document TypeArticle
KeywordPleural effusion ADA monocyte ratio differential diagnosis tuberculous pleurisy malignant effusion empyema value
WOS KeywordDIETARY SUPPLEMENTATION ; LYMPHOCYTE ; PARAMETERS ; DEFICIENCY ; CANCER ; GINGER
Abstract

Objective: To analyze the value of adenosine deaminase (ADA) level and monocyte ratio in pleural effusion to differentiate tuberculous pleurisy from malignant effusion and empyema. Methods: One hundred fifteen patients with pleural effusion admitted to our hospital from January 2019 to January 2020 were selected and divided into the tuberculous pleurisy group (n = 68), the malignant pleural effusion group (n = 25), and the empyema group (n = 22) by pathological examination. After admission, all patients underwent pleural puncture and drainage or catheterization. The first pleural effusion was collected and placed in the collection tube for ADA, CA125, nucleated cell count and single-factor analysis. The values of ADA, CA125, nucleated cell count and monocyte ratio in each group were compared. An ROC curve was used to analyze the value of ADA and CA125 in differentiating tuberculous pleurisy from malignant effusion and empyema. Results: The proportion of monocytes in pleural effusion of the tuberculous pleurisy group and the malignant pleural effusion group was significantly higher than that of the empyema group, and the number of nucleated cells was significantly lower than that of the empyema group; the proportion of monocytes in pleural effusion of the tuberculous pleurisy group was significantly higher than that of the malignant pleural effusion group, and the number of nucleated cells was significantly lower than that of the malignant pleural effusion group (P<0.05). The ADA of the tuberculous pleurisy group and the malignant pleural effusion group was significantly lower than that of the empyema group, and CA125 was significantly higher than that of the empyema group; ADA of the tuberculous pleurisy group was significantly higher than that of the malignant pleural effusion group, and CA125 was significantly lower than that of the malignant pleural effusion group; the difference was statistically significant (P<0.05). ROC curve analysis showed that the AUC of ADA in the diagnosis of tuberculous pleurisy was 0.785, the AUC of monocyte ratio in the diagnosis of tuberculous pleurisy was 0.685, the AUC of combined diagnosis of tuberculous pleurisy with ADA was 0.845, the AUC of ADA diagnosis of malignant effusion was 0.815, the AUC of monocyte ratio in the diagnosis of malignant effusion was 0.715, and the AUC of combined diagnosis of malignant effusion was 0.925. Conclusion: The level of ADA and the proportion of monocytes in pleural effusion can be used as important test indexes to distinguish tuberculous pleurisy from malignant effusion and empyema, and the combination of the two has the highest value and can be widely used in clinical practice.

PublisherCARBONE EDITORE
Publication PlacePALERMO
ISSN0393-6384
EISSN2283-9720
Volume38Issue:1Pages:109-113
DOI10.19193/0393-6384_2022_1_16
Page Number5
WOS SubjectMedicine, General & Internal
WOS Research AreaGeneral & Internal Medicine
WOS IDWOS:000754153500016
Indexed BySCIE ; SCOPUS
URL查看原文
scopusid2-s2.0-85124581920
Corresponding author address[Chen, Shaojie]Chengnan Street, Yueqing City, Wenzhou City, Zhejiang Province, China
scopus subject classificationMedicine (all)
Citation statistics
Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
Identifierhttps://kms.wmu.edu.cn/handle/3ETUA0LF/16559
Collection
Corresponding AuthorChen, Shaojie
Affiliation
1.Department of Thoracic Surgery,Yueqing Hospital Affiliated,Wenzhou Medical University (Wenzhou Medical College),Wenzhou,325600,China;
2.Department of Respiratory and Critical Care Medicine,Yueqing Hospital Affiliated,Wenzhou Medical University,Zhejiang Medical University,Wenzhou,325600,China;
3.Department of Infection,Yueqing Hospital Affiliated,Wenzhou Medical University,Wenzhou,325600,China;
4.Department of Respiratory and Critical Care Medicine,Yueqing Hospital Affiliated,Wenzhou Medical University,Wenzhou,325600,China;
5.Department of Thoracic Surgery,Yueqing Hospital Affiliated,Wenzhou Medical University,Medical College of Zhejiang University,Wenzhou,325600,China
First Author Affilication附属乐清医院(乐清市人民医院)
First Signature Affilication附属乐清医院(乐清市人民医院)
Recommended Citation
GB/T 7714
Nan, Hailin,Li, Jifa,Zheng, Qiongna,et al. THE VALUE OF ADA LEVEL AND MONOCYTE RATIO IN PLEURAL EFFUSION TO DIFFERENTIATE TUBERCULOUS PLEURISY FROM MALIGNANT EFFUSION AND EMPYEMA[J]. ACTA MEDICA MEDITERRANEA,2022,38(1):109-113.
APA Nan, Hailin, Li, Jifa, Zheng, Qiongna, Ye, Hua, & Chen, Shaojie. (2022). THE VALUE OF ADA LEVEL AND MONOCYTE RATIO IN PLEURAL EFFUSION TO DIFFERENTIATE TUBERCULOUS PLEURISY FROM MALIGNANT EFFUSION AND EMPYEMA. ACTA MEDICA MEDITERRANEA, 38(1), 109-113.
MLA Nan, Hailin,et al."THE VALUE OF ADA LEVEL AND MONOCYTE RATIO IN PLEURAL EFFUSION TO DIFFERENTIATE TUBERCULOUS PLEURISY FROM MALIGNANT EFFUSION AND EMPYEMA".ACTA MEDICA MEDITERRANEA 38.1(2022):109-113.

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