Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis

doi:10.7314/APJCP.2014.15.17.7251

科研成果详情

题名	Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis
作者	Lin, Zhuo1; Chen, Li 2; Song, Mei 1; Shi, Ke-Qing 1; Tang, Kai-Fu 2
发表日期	2014-12-31
发表期刊	ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	miR-34b/c rs4938723 polymorphism cancer meta-analysis
其他关键词	POTENTIALLY FUNCTIONAL POLYMORPHISM ; PROMOTER REGION ; RISK ; MICRORNA ; PRI-MIR-34B/C
摘要	MicroRNAs (miRNAs) act as tumor suppressors or promoters in neoplasia by regulating relative geneexpression. The association between a single nucleotide polymorphism (SNP) rs4938723 in miR-34b/c and susceptibility to cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed, Web of Science and Embase to identify all relevant studies in this meta-analysis with 6,036 cases and 6,204 controls. We found that the miR-34b/c rs4938723 polymorphism was significantly associated with increased risk of cancers in the heterozygous model (TC versus TT, OR=1.09, 95% CI=1.01-1.18, P=0.02). Subgroup analysis also revealed increased risk for Asian ethnicity in the heterozygous model (TC versus TT, OR=1.12, 95% CI=1.02-1.22, P=0.02), but decreased risk of colorectal cancer in homozygote model (CC versus TT, OR=0.66, 95% CI=0.47-0.92, P=0.02) and in the recessive model (CC versus TC+TT, OR=0.67, 95% CI=0.48-0.93, P=0.02) by cancer type. The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decrease susceptibility to colorectal cancer. Well-designed studies with larger sample size are required to further validate the results.
出版者	ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
出版地	GYEONGGI-DO
ISSN	1513-7368
卷号	15 期号:17 页码:7251-7255
DOI	10.7314/APJCP.2014.15.17.7251
页数	5
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000343833100043
收录类别	SCIE ; SCOPUS
URL	查看原文
Scopus记录号	2-s2.0-84907275754
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1650
专题	附属第一医院基因组医学研究院
通讯作者	Tang, Kai-Fu
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Inst Hepatol, Dept Infect & Liver Dis, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Inst Genom Med, Wenzhou, Peoples R China
推荐引用方式 GB/T 7714	Lin, Zhuo,Chen, Li,Song, Mei,et al. Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(17):7251-7255.
APA	Lin, Zhuo, Chen, Li, Song, Mei, Shi, Ke-Qing, & Tang, Kai-Fu. (2014). Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 15(17), 7251-7255.
MLA	Lin, Zhuo,et al."Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.17(2014):7251-7255.