Glutathione prevents chronic oscillating glucose intake-induced beta-cell dedifferentiation and failure

doi:10.1038/s41419-019-1552-y

科研成果详情

题名	Glutathione prevents chronic oscillating glucose intake-induced beta-cell dedifferentiation and failure
作者	Zhang, Jitai 1; An, Hui1; Ni, Kaidi 1; Chen, Bin 2; Li, Hui 1,2; Li, Yanqin 1; Sheng, Guilian 1; Zhou, Chuanzan1; Xie, Mengzhen 1; Chen, Saijing 1; Zhou, Tong1,3; Yang, Gaoxiong 1; Chen, Xiufang 4; Wu, Gaojun5; Jin, Shengwei6; Li, Ming 1
发表日期	2019-04-11
发表期刊	CELL DEATH & DISEASE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	CHRONIC OXIDATIVE STRESS ; INSULIN-SECRETION ; TOXICITY ; MECHANISM ; TRANSCRIPTION ; INHIBITION ; EXPRESSION ; HYPOXIA ; DISEASE ; GROWTH
摘要	Modern lifestyles have altered diet and metabolic homeostasis, with increased sugar intake, glycemic index, and prediabetes. A strong positive correlation between sugar consumption and diabetic incidence is revealed, but the underlying mechanisms remain obscure. Here we show that oral intake of long-term oscillating glucose (LOsG) (4 times/day) for 38 days, which produces physiological glycemic variability in rats, can lead to beta-cells gaining metabolic memory in reactive oxygen species (ROS) stress. This stress leads to suppression of forkhead box O1 (FoxO1) signaling and subsequent upregulation of thioredoxin interacting protein, inhibition of insulin and SOD-2 expression, re-expression of Neurog3, and beta-cell dedifferentiation and functional failure. LOsG-treated animals develop prediabetes exhibiting hypoinsulinemia and glucose intolerance. Dynamic and timely administration of antioxidant glutathione prevents LOsG/ROS-induced beta-cell failure and prediabetes. We propose that ROS stress is the initial step in LOsG-inducing prediabetes. Manipulating glutathione-related pathways may offer novel options for preventing the occurrence and development of diabetes.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670336]; Wenzhou Grant for Scientific Talents [RX2016003]; Wenzhou Science and Technology Bureau
出版者	NATURE PUBLISHING GROUP
出版地	LONDON
ISSN	2041-4889
卷号	10 期号:4 页码:321
DOI	10.1038/s41419-019-1552-y
页数	13
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000468660000002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30975975
PMC记录号	PMC6459929
SCOPUSEID	2-s2.0-85064256404
通讯作者地址	[Li, Ming]Cardiac Regeneration Research Institute,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Immunology;Cellular and Molecular Neuroscience;Cell Biology;Cancer Research
TOP期刊	TOP期刊
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16417
专题	基础医学院（机能实验教学中心）_基础医学研究中心_心脏再生医学研究所第一临床医学院（信息与工程学院）、附属第一医院附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Li, Ming
作者单位	1.Cardiac Regeneration Research Institute,Wenzhou Medical University,Wenzhou,China; 2.Department of Medical Ultrasound,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Gynecology and Obstetrics,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Biochemistry,School of Basic Medical Science,Whenzhou Medical University,Wenzhou,China; 5.The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 6.Department of Anesthesia and Critical Care,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Zhang, Jitai,An, Hui,Ni, Kaidi,et al. Glutathione prevents chronic oscillating glucose intake-induced beta-cell dedifferentiation and failure[J]. CELL DEATH & DISEASE,2019,10(4):321.
APA	Zhang, Jitai., An, Hui., Ni, Kaidi., Chen, Bin., Li, Hui., ... & Li, Ming. (2019). Glutathione prevents chronic oscillating glucose intake-induced beta-cell dedifferentiation and failure. CELL DEATH & DISEASE, 10(4), 321.
MLA	Zhang, Jitai,et al."Glutathione prevents chronic oscillating glucose intake-induced beta-cell dedifferentiation and failure".CELL DEATH & DISEASE 10.4(2019):321.