Resting state brain default network in patients with motor aphasia resulting from cerebral infarction

doi:10.1007/s11434-014-0491-3

科研成果详情

题名	Resting state brain default network in patients with motor aphasia resulting from cerebral infarction
作者	Wang, Xin 1; Wang, Meihao1; Wang, Weizhuo 2; Liu, Huiru1; Tao, Jiejie1; Yang, Chuang3; Li, Jiance1
发表日期	2014-11
发表期刊	CHINESE SCIENCE BULLETIN 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cerebral infarction Motor aphasia Resting state Brain default network Functional magnetic resonance imaging Functional connectivity
其他关键词	EXECUTIVE CONTROL ; WORD RETRIEVAL ; MODE ; CORTEX ; FMRI ; HYPOTHESIS ; RECOVERY ; MEMORY
摘要	To explore the brain default mode network (DMN) in patients with motor aphasia resulting from cerebral infarction, we used resting state functional magnetic resonance imaging (fMRI) to investigate the possible neural mechanism. Thirteen patients with motor aphasia resulting from cerebral infarction and ten matched controls were selected in this study. All subjects were examined using resting state fMRI. We chose the posterior cingulate cortex as the region of interest and then used functional connectivity analysis to calculate the DMN functional connectivity and analyze differences in the functional connectivity between the two groups. Compared with normal controls, aphasia patient group showed a significantly decreased functional connectivity in bilateral medial frontal gyrus, superior frontal gyrus, middle frontal gyrus, middle temporal gyrus, precuneus and cuneus. The aphasia patient group showed increased functional connectivity mainly in bilateral medial frontal gyrus, middle frontal gyrus, inferior frontal gyrus, precentral gyrus, insula. The DMN in cerebral infarction motor aphasia patients showed significantly decreased functional connectivity in the resting state. The DMN most likely plays an important role in motor aphasia resulting from cerebral infarction. Furthermore, functional connectivity in the brain regions surrounding the left and right Broca's areas was significantly enhanced due to compensatory mechanisms. This may be helpful for the recovery of language function in cerebral infarction patients with motor aphasia.
出版者	SCIENCE PRESS
出版地	BEIJING
ISSN	1001-6538
EISSN	1861-9541
卷号	59 期号:31 页码:4069-4076
DOI	10.1007/s11434-014-0491-3
页数	8
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000342421100016
收录类别	SCIE ; 万方 ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-84907860883
通讯作者地址	[Wang, Meihao]Department of Radiology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Multidisciplinary
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16381
专题	第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科附属第一医院精神医学学院_精神医学系
通讯作者	Wang, Meihao
作者单位	1.Department of Radiology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Radiology,Nankai Hospital of Tianjin,Tianjin,300000,China; 3.Department of Psychiatry,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Xin,Wang, Meihao,Wang, Weizhuo,et al. Resting state brain default network in patients with motor aphasia resulting from cerebral infarction[J]. CHINESE SCIENCE BULLETIN,2014,59(31):4069-4076.
APA	Wang, Xin., Wang, Meihao., Wang, Weizhuo., Liu, Huiru., Tao, Jiejie., ... & Li, Jiance. (2014). Resting state brain default network in patients with motor aphasia resulting from cerebral infarction. CHINESE SCIENCE BULLETIN, 59(31), 4069-4076.
MLA	Wang, Xin,et al."Resting state brain default network in patients with motor aphasia resulting from cerebral infarction".CHINESE SCIENCE BULLETIN 59.31(2014):4069-4076.

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