Trauma could as a triggering factor for development of acral lentiginous melanoma: a clinicopathologic study of 56 cases

科研成果详情

题名	Trauma could as a triggering factor for development of acral lentiginous melanoma: a clinicopathologic study of 56 cases
作者	Li, Yangyang 1; Chen, Hanbin 1; Chen, Guorong1; Liu, Jingjing2; Zhu, Haigang 3; Nugasur, Bhawneeta 3; Li, Zhiming2; Ye, Teng 4
发表日期	2016-12-31
发表期刊	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Acral lentiginous melanoma clinicopathologic study inflammation trauma
其他关键词	SUBUNGUAL MELANOMA ; MALIGNANT-MELANOMA ; EPIDEMIOLOGY ; PROGNOSIS
摘要	Background: The knowledge about Acral Lentiginous Melanoma's clinical presentation and histopathologic characteristics in East Asians is limited. Moreover, the association between trauma and melanoma has been a controversial issue. Methods: In order to assess clinical and pathological characteristics associated with melanoma, 56 Chinese patients with a trauma history have been investigated. The patients' demographic data and pathological observation has been studied. Statistical analyses including survival and univariate analyses of factor associated with survival were respectively performed by Kaplan-Meier method and the related analysis with traumatic events in acral lentiginous melanoma. Results: Post-trauma melanoma refers to melanoma occurring after trauma to the primary anatomic site. Our data collected from the two groups shows that it is statistically significant (P < 0.05) with age, cellular morphology and ulceration. Among the 56 acral lentiginous melanoma patients, the detailed descriptions of the anatomic sites of primary lesions were noted which included the nails of the thumbs and toes (13, 23.3%), the heels and plantar of the feet (39, 69.6%, 21 on the right, 18 on the left) and other sites (4, 7.1%). The prognosis of acral lentiginous melanoma was described to be significantly better with post-trauma melanoma than trauma-unrelated melanoma. Conclusions: Our findings provide epidemiological evidence for a potential association between traumatic events and acral lentiginous melanoma. In addition to genetic factors, trauma may also contribute to the development of melanoma with its influence on vasculogenisis and inflammation.
资助项目	National Natural Scientific Fund [81272987]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY12H-11011]; Zhejiang Science Technology [2013C24031]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1936-2625
卷号	9 期号:8 页码:7800-7806
页数	7
WOS类目	Oncology ; Pathology
WOS研究方向	Oncology ; Pathology
WOS记录号	WOS:000386653400005
收录类别	SCIE ; SCOPUS
URL	查看原文
Scopus记录号	2-s2.0-84994222165
通讯作者地址	[Ye, Teng]Department of Dermatology,Wenzhou Hospital of Integrated Chinese and Western Medicine,Wenzhou Children's Hospital,Wenzhou, Zhejiang,325000,China
scopus学科分类	Pathology and Forensic Medicine;Histology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16374
专题	基础医学院（机能实验教学中心）_病理学与病理生理学系附属第一医院_皮肤科
通讯作者	Ye, Teng
作者单位	1.Department of Pathology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China; 2.Department of Dermatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China; 3.Department of Dermatology,Wenzhou Medical University,Wenzhou, Zhejiang,China; 4.Department of Dermatology,Wenzhou Hospital of Integrated Chinese and Western Medicine,Wenzhou Children's Hospital,Wenzhou, Zhejiang,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Li, Yangyang,Chen, Hanbin,Chen, Guorong,et al. Trauma could as a triggering factor for development of acral lentiginous melanoma: a clinicopathologic study of 56 cases[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2016,9(8):7800-7806.
APA	Li, Yangyang., Chen, Hanbin., Chen, Guorong., Liu, Jingjing., Zhu, Haigang., ... & Ye, Teng. (2016). Trauma could as a triggering factor for development of acral lentiginous melanoma: a clinicopathologic study of 56 cases. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 9(8), 7800-7806.
MLA	Li, Yangyang,et al."Trauma could as a triggering factor for development of acral lentiginous melanoma: a clinicopathologic study of 56 cases".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 9.8(2016):7800-7806.