Modified 'sandwich' injection with or without ligation for variceal bleeding in patients with both esophageal and gastric varices: a retrospective cohort study

doi:10.1080/00365521.2020.1803959

科研成果详情

题名	Modified 'sandwich' injection with or without ligation for variceal bleeding in patients with both esophageal and gastric varices: a retrospective cohort study
作者	Hu, Tingting1; Stock, Simon 2; Hong, Wandong1; Chen, Yongping3,4,5
发表日期	2020-10-02
发表期刊	SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Esophagogastric variceal bleeding ligation modified 'sandwich' injection predictor rebleeding
其他关键词	SECONDARY PROPHYLAXIS ; PORTAL-HYPERTENSION ; CONSENSUS WORKSHOP ; CLINICAL-OUTCOMES ; SCLEROTHERAPY ; N-BUTYL-2-CYANOACRYLATE ; THERAPY ; COMPLICATIONS ; MANAGEMENT ; HEMORRHAGE
摘要	Objectives Esophagogastric variceal bleeding (EGVB) is a serious disease with high mortality. Endoscopic therapy has long been shown to be effective but the optimum technique is still unclear. We aimed to investigate the efficacy, safety and predictive factors of 1-year rebleeding of modified 'sandwich' injection combined with esophageal variceal ligation (EVL) for treating EGVB. Methods A retrospective analysis was performed of 100 patients with EGVB who underwent modified 'sandwich' injection with or without EVL (EVL + and EVL - group). Patient follow-up was 1 year. Outcomes such as control of bleeding, rebleeding, complication rate and mortality were compared. Further, prognostic factors for rebleeding at one year were estimated. Results No significant differences between two groups regarding initial bleeding control, complications, 6-week rebleeding or mortality in 1-year were observed. Rebleeding rate at 1-year of EVL - group was significantly higher than EVL + group (40 vs 20%,p = .029). Independent predictors of rebleeding at 1-year were gender, bilirubin and whether EVL was combined with injection. Conclusions Based on this single-center retrospective study, both of the two kinds therapies appeared to have relatively favorable outcomes. With respect to the rebleeding rate at 1-year, modified 'sandwich' injection combined with EVL may be superior to modified 'sandwich' injection alone.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770585]; National Science and Technology Major Project of China [2017ZX10202201, 2017ZX10203201, 2018ZX10725506-001]
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	0036-5521
EISSN	1502-7708
卷号	55 期号:10 页码:1219-1224
DOI	10.1080/00365521.2020.1803959
页数	6
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000558525500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	32780613
Scopus记录号	2-s2.0-85089453391
通讯作者地址	[Hong, Wandong]Department of Gastroenterology and Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325025,China ; [Chen, Yongping]Department of Infectious Diseases,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325025,China
scopus学科分类	Gastroenterology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/16163
专题	附属第一医院_肝胆外科附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_精准医学中心实验室
通讯作者	Hong, Wandong; Chen, Yongping
作者单位	1.Department of Gastroenterology and Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Surgery,World Mate Emergency Hospital,Battambang,Cambodia; 3.Department of Infectious Diseases,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases,Wenzhou Medical University,Wenzhou,China; 5.Hepatology Institute of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Hu, Tingting,Stock, Simon,Hong, Wandong,et al. Modified 'sandwich' injection with or without ligation for variceal bleeding in patients with both esophageal and gastric varices: a retrospective cohort study[J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY,2020,55(10):1219-1224.
APA	Hu, Tingting, Stock, Simon, Hong, Wandong, & Chen, Yongping. (2020). Modified 'sandwich' injection with or without ligation for variceal bleeding in patients with both esophageal and gastric varices: a retrospective cohort study. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 55(10), 1219-1224.
MLA	Hu, Tingting,et al."Modified 'sandwich' injection with or without ligation for variceal bleeding in patients with both esophageal and gastric varices: a retrospective cohort study".SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 55.10(2020):1219-1224.