Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study

doi:10.2147/CIA.S187142

科研成果详情

题名	Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study
作者	Chen, Huijun 1; Liu, Yuntao 1; Huang, Guiqian1; Zhu, Jie 2; Feng, Wenqian 2; He, Jincai1
发表日期	2018-12-31
发表期刊	CLINICAL INTERVENTIONS IN AGING 影响因子和分区
语种	英语
原始文献类型	Article
关键词	vitamin D cognitive impairment ischemic stroke Mini-Mental State Examination
其他关键词	25-HYDROXYVITAMIN D PREDICTS ; LONG-TERM RISK ; ALZHEIMERS-DISEASE ; OLDER-ADULTS ; DENSITY-LIPOPROTEIN ; D-RECEPTOR ; DEMENTIA ; CALCIUM ; DECLINE
摘要	Objective: Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month. Methods: In total, 354 ischemic stroke patients were consecutively enrolled in the study and received 1-month follow-up. The serum levels of vitamin D were measured within 24 hours after admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after acute ischemic stroke. Cognitive impairment was defined according to different education levels. Results: According to MMSE scores, 114 participants (32.2%) had cognitive impairment at 1 month. Patients with vitamin D deficiency were more likely to have cognitive impairment than those with vitamin D insufficiency and vitamin D sufficiency (P<0.001). After adjusting for potential confounders in our Cox proportional hazards model, vitamin D deficiency was independently associated with the development of cognitive impairment in acute ischemic stroke patients. Conclusion: Independent of established risk factors, vitamin D deficiency in the short-term phase of ischemic stroke was associated with a higher incidence of 1-month cognitive impairment.
资助项目	National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873799]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2015BAI13B01]; Wenzhou Municipal Sci-Tech Bureau Program [Y20160002]
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1178-1998
EISSN	1178-1998
卷号	13 页码:2503-2509
DOI	10.2147/CIA.S187142
页数	7
WOS类目	Geriatrics & Gerontology
WOS研究方向	Geriatrics & Gerontology
WOS记录号	WOS:000452759800002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30573955
PMC记录号	PMC6292227
SCOPUSEID	2-s2.0-85058690800
通讯作者地址	[He, Jincai]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Geriatrics and Gerontology
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1588
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学_精神卫生科
通讯作者	He, Jincai
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Mental Health,Mental Health School,Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Huijun,Liu, Yuntao,Huang, Guiqian,et al. Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study[J]. CLINICAL INTERVENTIONS IN AGING,2018,13:2503-2509.
APA	Chen, Huijun, Liu, Yuntao, Huang, Guiqian, Zhu, Jie, Feng, Wenqian, & He, Jincai. (2018). Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study. CLINICAL INTERVENTIONS IN AGING, 13, 2503-2509.
MLA	Chen, Huijun,et al."Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study".CLINICAL INTERVENTIONS IN AGING 13(2018):2503-2509.