In vitro maturation and fertilization of oocytes from unstimulated ovaries in infertile women with polycystic ovary syndrome

doi:10.1016/j.fertnstert.2008.03.059

科研成果详情

题名	In vitro maturation and fertilization of oocytes from unstimulated ovaries in infertile women with polycystic ovary syndrome
作者	Zhao, Jun-Zhao1; Zhou, Wei ; Zhang, Wei ; Ge, Hong-Shan2; Huang, Xue-Feng ; Lin, Jin-Ju
发表日期	2009-06
发表期刊	FERTILITY AND STERILITY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Infertility in vitro maturation polycystic ovary syndrome unstimulated ovaries
其他关键词	CYCLES
摘要	Objective: To evaluate the effects of in vitro maturation and fertilization of oocytes from unstimulated ovaries in infertile women with polycystic ovary syndrome (PCOS). Design: Retrospective study. Setting: Reproductive Medicine Center, First Affiliated Hospital of Wenzhou Medical College, People's Republic of China. Patient(s): One hundred eighteen women with PCOS undergoing 152 cycles of in vitro maturation treatment. Intervention(s): Oocyte retrieval was carried out by ultrasound-guided puncture on days 9-14 of the cycle. The oocytes were cultured in vitro using maturation culture medium, which consisted of M-199 + 20% fetal bovine serum (FBS) + 75 mIU/mL recombinant FSH +/- 0.5 IU/mL hCG. After the oocytes had matured in vitro, fertilization and embryo transfer were performed. Main Outcome Measure(s): Rates of clinical pregnancy, multiple pregnancies, and live birth. Result(s): Relatively optimal laboratory results were obtained in this study. Embryo transfer was performed in 140 cycles, with a clinical pregnancy rate (PR) of 40.0% per transfer. Fifty-six babies have been born and there are 10 ongoing pregnancies. The overall multiple PR was 33.93%. Conclusion(s): Our results show that using in vitro matured oocytes from unstimulated ovaries could be offered as an alternative to conventional IVF in women with PCOS, and future work should address ways to decrease the incidence of multiple pregnancies. (Fertil Steril (R) 2009;91:2568-71. (c) 2009 by American Society for Reproductive Medicine.)
出版者	ELSEVIER SCIENCE INC
出版地	NEW YORK
ISSN	0015-0282
EISSN	1556-5653
卷号	91 期号:6 页码:2568-2571
DOI	10.1016/j.fertnstert.2008.03.059
页数	4
WOS类目	Obstetrics & Gynecology ; Reproductive Biology
WOS研究方向	Obstetrics & Gynecology ; Reproductive Biology
WOS记录号	WOS:000266801400043
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	18579137
SCOPUSEID	2-s2.0-67349139183
自科自定义期刊分类	T3(B)类
通讯作者地址	[Zhao, Jun-Zhao]First Affiliated Hosp, Dept Reprod Med, Wenzhou Med Coll, Reprod Med Ctr, Wenzhou, Zhejiang, Peoples R China.
TOP期刊	TOP期刊
引用统计	被引频次：36[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15883
专题	附属第一医院_生殖医学中心附属第二医院_生殖医学中心
通讯作者	Zhao, Jun-Zhao
作者单位	1.First Affiliated Hosp, Dept Reprod Med, Wenzhou Med Coll, Reprod Med Ctr, Wenzhou, Zhejiang, Peoples R China; 2.Second Affiliated Hosp, Reprod Hlth Ctr, Wenzhou Med Coll, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院_生殖医学中心
通讯作者单位	附属第一医院_生殖医学中心
第一作者的第一单位	附属第一医院_生殖医学中心
推荐引用方式 GB/T 7714	Zhao, Jun-Zhao,Zhou, Wei,Zhang, Wei,et al. In vitro maturation and fertilization of oocytes from unstimulated ovaries in infertile women with polycystic ovary syndrome[J]. FERTILITY AND STERILITY,2009,91(6):2568-2571.
APA	Zhao, Jun-Zhao, Zhou, Wei, Zhang, Wei, Ge, Hong-Shan, Huang, Xue-Feng, & Lin, Jin-Ju. (2009). In vitro maturation and fertilization of oocytes from unstimulated ovaries in infertile women with polycystic ovary syndrome. FERTILITY AND STERILITY, 91(6), 2568-2571.
MLA	Zhao, Jun-Zhao,et al."In vitro maturation and fertilization of oocytes from unstimulated ovaries in infertile women with polycystic ovary syndrome".FERTILITY AND STERILITY 91.6(2009):2568-2571.