Caveolin-1, E-cadherin and beta-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis

doi:10.1007/s11670-012-0023-0

科研成果详情

题名	Caveolin-1, E-cadherin and beta-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis
作者	Sun, Guo-yang1; Wu, Jun-xia 2; Wu, Jian-sheng1; Pan, Yu-ting 1; Jin, Rong1,3
发表日期	2012-03
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Gastric carcinoma Caveolin-1 E-cadherin beta-catenin Immunohistochemistry
其他关键词	PROGNOSTIC-SIGNIFICANCE ; CELL-PROLIFERATION ; EXPRESSION ; CANCER ; ADENOCARCINOMA ; TUMORIGENESIS ; PROGRESSION ; METASTASIS
摘要	To investigate the expressions of caveolin-1, E-cadherin and beta-catenin in gastric carcinoma, precancerous gastric and chronic non-atrophic gastritis tissues, and evaluate the correlation of these expressions with the development of gastric cancer. The expressions of caveolin-1, E-cadherin and beta-catenin were detected by biotin-streptavidin-peroxidase (SP) immunohistochemistry on 58 gastric cancer tissues, 40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues. The correlation between the expressions of caveolin-1, E-cadherin and beta-catenin, and the clinicopathologic parameters of gastric cancer was analyzed retrospectively. The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues (P < 0.01). An abnormal rate of beta-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues (P < 0.01). Moreover, low expressions of caveolin-1, E-cadherin and beta-catenin correlated with tumor size, depth of invasion, lymph node metastasis and TNM stage (P < 0.05). The positive rates of caveolin-1 and E-cadherin expressions decreased (P < 0.01), while an abnormal rate of beta-catenin expression increased inversely, with the degree of atypical hyperplasia (P < 0.01). Caveolin-1 expression correlated positively with E-cadherin (r=0.41, P < 0.05). Caveolin-1 (r=-0.36, P < 0.05) and E-cadherin (r=-0.45, P < 0.05) expressions negatively correlated with abnormal beta-catenin expression. These results suggested that dysregulated expressions of caveolin-1, E-cadherin and beta-catenin correlated with the development of gastric cancer and its biological behavior.
资助项目	Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [Y206750]; Zhejiang Foundation for Development of Science and Technology, China [2008C33066]; Wenzhou Foundation for Development of Science and Technology, China [H20060026]
出版者	CHINESE JOURNAL CANCER RESEARCH CO
出版地	BEIJING
ISSN	1000-9604
EISSN	1993-0631
卷号	24 期号:1 页码:23-28
DOI	10.1007/s11670-012-0023-0
页数	6
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000300313500004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	23359759
PMC记录号	PMC3555256
SCOPUSEID	2-s2.0-84863695843
通讯作者地址	[Jin, Rong]Wenzhou Med Coll, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou 325000, Peoples R China.
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15668
专题	附属第一医院_消化内科第一临床医学院（信息与工程学院）、附属第一医院_流行病学_流行病
通讯作者	Jin, Rong
作者单位	1.Wenzhou Med Coll, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou 325000, Peoples R China; 2.Shaoxing Municipal Peoples Hosp, Dept Gastroenterol, Shaoxing 312000, Peoples R China; 3.Wenzhou Med Coll, Affiliated Hosp 1, Dept Epidemiol, Wenzhou 325000, Peoples R China
第一作者单位	附属第一医院_消化内科
通讯作者单位	附属第一医院_消化内科
第一作者的第一单位	附属第一医院_消化内科
推荐引用方式 GB/T 7714	Sun, Guo-yang,Wu, Jun-xia,Wu, Jian-sheng,et al. Caveolin-1, E-cadherin and beta-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis[J]. CHINESE JOURNAL OF CANCER RESEARCH,2012,24(1):23-28.
APA	Sun, Guo-yang, Wu, Jun-xia, Wu, Jian-sheng, Pan, Yu-ting, & Jin, Rong. (2012). Caveolin-1, E-cadherin and beta-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis. CHINESE JOURNAL OF CANCER RESEARCH, 24(1), 23-28.
MLA	Sun, Guo-yang,et al."Caveolin-1, E-cadherin and beta-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis".CHINESE JOURNAL OF CANCER RESEARCH 24.1(2012):23-28.