Differential expression of Notch1 intracellular domain and p21 proteins, and their clinical significance in gastric cancer

doi:10.3892/ol.2013.1751

科研成果详情

题名	Differential expression of Notch1 intracellular domain and p21 proteins, and their clinical significance in gastric cancer
作者	Luo, Ding-Hai 1,2; Zhou, Qin1; Hu, Sun-Kuan1; Xia, Yi-Qun1; Xu, Chao-Chao 1; Lin, Tie-Su1; Pan, Yu-Ting 1; Wu, Jian-Sheng1; Jin, Rong1,3
发表日期	2014-02
发表期刊	ONCOLOGY LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Notch1 intracellular doman p21 gastric cancer prognosis biomarkers
其他关键词	CELL-CYCLE ARREST ; DOWN-REGULATION ; TUMOR-GROWTH ; PATHWAY ; INHIBITION ; PROGRESSION ; ACTIVATION ; FATE ; P53
摘要	Changes in the expression of the Notch1 intracellular domain (NICD) and p21 proteins have been shown to be closely associated with the development and progression of a number of cancers. The present study aimed to investigate the expression levels of the two proteins in gastric carcinoma and precancerous lesions, and to determine the clinical significance of this. A total of 109 gastric cancer, 57 precancerous gastric lesion, 50 chronic superficial gastritis and 17 normal gastric mucosa patients were recruited for immunohistochemical staining of NICD and p21 protein expression. The protein expression levels in the gastric cancer patient samples were associated with the clinicopathological and survival data. NICD protein levels were upregulated gradually from normal gastric mucosae through chronic superficial gastritis and precancerous gastric lesions to gastric cancer tissues (P<0.01), whereas p21 protein levels were downregulated accordingly (P<0.01). Increased NICD and a loss of p21 expression were closely associated with tumor dedifferentiation, depth of tumor invasion, lymph node metastasis, surface morphology and Lauren classification in gastric cancer. Thus, NICD expression was inversely associated with p21 expression. In addition, the overall survival rate was greater in NICD- and P21(+) patients than in NICD+ and P21(-) patients, respectively (P<0.05). The COX regression multivariate analysis revealed that NICD+, p21(-), depth of tumor invasion and lymph node metastasis were all independent prognostic factors for patients with gastric cancer. NICD and p21 proteins are differentially expressed in gastric cancer and the aberrant expression of these proteins is associated with an advanced tumor stage, tumor metastasis and overall patient survival. Future studies are required to further evaluate the two proteins as novel prognostic markers for patients with gastric cancer.
资助项目	Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [Y2101458]; Innovation Technology Project for High-Level Personnel of Wenzhou City [201011]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1792-1074
EISSN	1792-1082
卷号	7 期号:2 页码:471-478
DOI	10.3892/ol.2013.1751
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000332693400036
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	24396472
PMC记录号	PMC3881918
通讯作者地址	[Jin, Rong]Wenzhou Med Coll, Affiliated Hosp 1, Dept Epidemiol, 96 Fu Xue Rd, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15612
专题	附属第一医院_消化内科第一临床医学院（信息与工程学院）、附属第一医院_流行病学_流行病
通讯作者	Jin, Rong
作者单位	1.Wenzhou Med Coll, Affiliated Hosp 1, Dept Digest Dis, Wenzhou 325000, Zhejiang, Peoples R China; 2.Taizhou Hosp, Dept Gastroenterol, Linhai 317000, Zhejiang, Peoples R China; 3.Wenzhou Med Coll, Affiliated Hosp 1, Dept Epidemiol, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院_消化内科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_流行病学_流行病
第一作者的第一单位	附属第一医院_消化内科
推荐引用方式 GB/T 7714	Luo, Ding-Hai,Zhou, Qin,Hu, Sun-Kuan,et al. Differential expression of Notch1 intracellular domain and p21 proteins, and their clinical significance in gastric cancer[J]. ONCOLOGY LETTERS,2014,7(2):471-478.
APA	Luo, Ding-Hai., Zhou, Qin., Hu, Sun-Kuan., Xia, Yi-Qun., Xu, Chao-Chao., ... & Jin, Rong. (2014). Differential expression of Notch1 intracellular domain and p21 proteins, and their clinical significance in gastric cancer. ONCOLOGY LETTERS, 7(2), 471-478.
MLA	Luo, Ding-Hai,et al."Differential expression of Notch1 intracellular domain and p21 proteins, and their clinical significance in gastric cancer".ONCOLOGY LETTERS 7.2(2014):471-478.