Therapeutic effect of solifenacin combined with tamsulosin on benign prostatic hyperplasia with overactive bladder

科研成果详情

题名	Therapeutic effect of solifenacin combined with tamsulosin on benign prostatic hyperplasia with overactive bladder
作者	Chen, Siping 1; Wen, Huihuang 1; Zhou, Bin 3; Li, Jie 2
发表日期	2018
发表期刊	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Solifenacin tamsulosin benign prostatic hyperplasia overactive bladder curative effect observation
其他关键词	URINARY-TRACT SYMPTOMS ; OXIDATIVE STRESS ; HYPERACTIVITY ; POPULATION ; INJECTION ; MODEL ; OAB
摘要	Objective: To observe the clinical efficacy of solifenacin combined with tamsulosin in benign prostatic hyperplasia (BPH) with overactive bladder (OAB). Methods: One hundred and six patients with BPH and OAB were enrolled in Department of Urology Surgery, Ruian City People's Hospital. The patients were divided into control group and study group (53 cases for each group). In the control group, tamsulosin was used alone for 12 weeks. In the study group, solifenacin was added on the basis of the control group method for 12 weeks. International prostate symptom score (IPSS), overactive bladder symptom scores (OABSS), urine storage period symptom score (USPSS), voiding symptom score (VSS), maximum urinary flow rate (Qmax), residual urine volume (RUV), total effective rate, quality of life index (QOL), urinary nerve growth factor, and adverse reactions were analyzed and compared. Results: The general data of the two groups were statistically insignificant and comparable (P > 0.05). After treatment, the patients in the study group were superior to those in the control group in IPSS, OABSS, USPSS, VSS, and Qmax indicators. And the results of two groups were statistically different (P < 0.05). There was no significant difference in the residual urine volume between the two groups (P > 0.05). In terms of total efficiency, the study group was superior to the control group with statistical differences (P < 0.05). In terms of quality of life scores, the two groups were significantly improved after treatment (P < 0.05), and the quality of life scores in the study group after treatment were significantly better than those in the control group (P < 0.05). In terms of urine nerve growth factor, the two groups of patients significantly improved after treatment (P < 0.05), and the study group was statistically superior to the control group (P < 0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: The clinical efficacy of solifenacin combined with tamsulosin on benign prostatic hyperplasia combined with overactive bladder patients is better than that of tamsulosin alone and does not increase the incidence of side effects. It is worthy of clinical application.
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1940-5901
卷号	11 期号:12 页码:13820-13826
页数	7
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000454547200116
收录类别	SCIE
通讯作者地址	[Li, Jie]Ruian Peoples Hosp, Dept Pharm, 108 Wansong Rd, Ruian 325200, Zhejiang, Peoples R China.
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15594
专题	第一临床医学院（信息与工程学院）、附属第一医院_药学部
通讯作者	Li, Jie
作者单位	1.Ruian Peoples Hosp, Dept Urol, Ruian, Zhejiang, Peoples R China; 2.Ruian Peoples Hosp, Dept Pharm, 108 Wansong Rd, Ruian 325200, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Dept Pharm, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Chen, Siping,Wen, Huihuang,Zhou, Bin,et al. Therapeutic effect of solifenacin combined with tamsulosin on benign prostatic hyperplasia with overactive bladder[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2018,11(12):13820-13826.
APA	Chen, Siping, Wen, Huihuang, Zhou, Bin, & Li, Jie. (2018). Therapeutic effect of solifenacin combined with tamsulosin on benign prostatic hyperplasia with overactive bladder. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 11(12), 13820-13826.
MLA	Chen, Siping,et al."Therapeutic effect of solifenacin combined with tamsulosin on benign prostatic hyperplasia with overactive bladder".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 11.12(2018):13820-13826.