Selenotranscriptomic analyses identify signature selenoproteins in brain regions in a mouse model of Parkinson’s disease.

doi:10.1371/journal.pone.0163372

科研成果详情

题名	Selenotranscriptomic analyses identify signature selenoproteins in brain regions in a mouse model of Parkinson’s disease.
作者	Zhang, Xiong1,2; Ye, Yang-Lie 1; Zhu, Hui1; Sun, Sheng-Nan 2; Zheng, Jing 2; Fan, Hui-Hui2,4; Wu, Hong-Mei2,4; Chen, Song-Fang1; Cheng, Wen-Hsing 5; Zhu, Jian-Hong2,3,4
发表日期	2016-09-22
发表期刊	PLoS One. 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	GLUTATHIONE-PEROXIDASE ; SUBSTANTIA-NIGRA ; GENE-EXPRESSION ; ENDOPLASMIC-RETICULUM ; OXIDATIVE DAMAGE ; RAT MODEL ; SELENIUM ; MICE ; DEFICIENT ; NEUROTOXICITY
摘要	Genes of selenoproteome have been increasingly implicated in various aspects of neurobiology and neurological disorders, but remain largely elusive in Parkinson's disease (PD). In this study, we investigated the selenotranscriptome (24 selenoproteins in total) in five brain regions (cerebellum, substantia nigra, cortex, pons and hippocampus) by real time qPCR in a two-phase manner using a mouse model of chronic PD. A wide range of changes in selenotranscriptome was observed in a manner depending on selenoproteins and brain regions. While Selv mRNA was not detectable and Dio1& 3 mRNA levels were not affected, 1, 11 and 9 selenoproteins displayed patterns of increase only, decrease only, and mixed response, respectively, in these brain regions of PD mice. In particular, the mRNA expression of Gpx1-4 showed only a decreased trend in the PD mouse brains. In substantia nigra, levels of 17 selenoprotein mRNAs were significantly decreased whereas no selenoprotein was up-regulated in the PD mice. In contrast, the majority of selenotranscriptome did not change and a few selenoprotein mRNAs that respond displayed a mixed pattern of up-and down-regulation in cerebellum, cortex, hippocampus, and/or pons of the PD mice. Gpx4, Sep15, Selm, Sepw1, and Sepp1 mRNAs were most abundant across all these five brain regions. Our results showed differential responses of selenoproteins in various brain regions of the PD mouse model, providing critical selenotranscriptomic profiling for future functional investigation of individual selenoprotein in PD etiology.
资助项目	Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LR13H020002, LY15H090021, LY16H250003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81571087]; Health Bureau of Zhejiang Province [2016ZB078]; Wenzhou Bureau of Science and Technology [Y20150005]
出版者	PUBLIC LIBRARY SCIENCE
出版地	SAN FRANCISCO
ISSN	1932-6203
卷号	11 期号:9 页码:e0163372.
DOI	10.1371/journal.pone.0163372
页数	15
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000383893200107
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27656880
PMC记录号	PMC5033372
SCOPUSEID	2-s2.0-84992187399
通讯作者地址	[Zhu, Jian-Hong]Wenzhou Med Univ, Dept Prevent Med, Wenzhou, Zhejiang, Peoples R China. ; [Zhu, Jian-Hong]Wenzhou Med Univ, Key Lab Watershed Sci & Hlth Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China. ; [Zhu, Jian-Hong]Wenzhou Med Univ, Inst Nutr & Dis, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Multidisciplinary
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/155877
专题	第二临床医学院、附属第二医院、育英儿童医院公共卫生学院附属第二医院附属第二医院_神经内科公共卫生学院_预防医学系
通讯作者	Zhu, Jian-Hong
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Neurol, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Dept Prevent Med, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Key Lab Watershed Sci & Hlth Zhejiang Prov, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Inst Nutr & Dis, Wenzhou, Zhejiang, Peoples R China; 5.Mississippi State Univ, Dept Food Sci Nutr & Hlth Promot, Mississippi State, MS 39762 USA
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 神经内科; 预防医学系
通讯作者单位	预防医学系; 温州医科大学
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Zhang, Xiong,Ye, Yang-Lie,Zhu, Hui,et al. Selenotranscriptomic analyses identify signature selenoproteins in brain regions in a mouse model of Parkinson’s disease.[J]. PLoS One.,2016,11(9):e0163372..
APA	Zhang, Xiong., Ye, Yang-Lie., Zhu, Hui., Sun, Sheng-Nan., Zheng, Jing., ... & Zhu, Jian-Hong. (2016). Selenotranscriptomic analyses identify signature selenoproteins in brain regions in a mouse model of Parkinson’s disease.. PLoS One., 11(9), e0163372..
MLA	Zhang, Xiong,et al."Selenotranscriptomic analyses identify signature selenoproteins in brain regions in a mouse model of Parkinson’s disease.".PLoS One. 11.9(2016):e0163372..