Involvement of the ERK signaling pathways in the NAc in propofol-seeking behavior induced by cues in rats.

doi:10.1016/j.pbb.2022.173447

科研成果详情

题名	Involvement of the ERK signaling pathways in the NAc in propofol-seeking behavior induced by cues in rats.
作者	Wang, Benfu1,2,3; Yang, Xiaowei3; Zhou, Wenhua 4; Zhu, Huaqiang 5; Lian, Qingquan3; Yang, Jianping 1
发表日期	2022-09
发表期刊	Pharmacology, biochemistry, and behavior 影响因子和分区
语种	英语
原始文献类型	Article
关键词	ERK NAc Propofol Psychological dependence Relapse U0126
其他关键词	ACTIVATED PROTEIN-KINASE ; DOPAMINE D1 RECEPTORS ; REGULATED KINASE ; NUCLEUS-ACCUMBENS ; AFFECTIVE STATE ; AMYGDALA ; INCUBATION ; HEROIN ; ABUSE ; RECONSOLIDATION
摘要	Propofol, an intravenous short-acting anesthetic, has the potential to induce craving and relapse. Accumulated evidence demonstrates that extracellular signal-regulated kinase (ERK) plays an essential role in drug reward and relapse. In the previous study, we demonstrated that the ERK signaling pathways in the Nucleus accumbens (NAc) were involved in propofol reward. However, the role of the ERK signaling pathways in propofol relapse is still unknown. We first trained rats to self-administer propofol for 14 days, then evaluated propofol-seeking behavior of relapse induced by a contextual cues and conditioned cues after 14-day withdrawal. Meanwhile, MEK inhibitor U0126 was used to investigate the role of the ERK signal pathways in propofol-seeking behavior induced by contextual cues and conditioned cues. Results showed that the number of active nose-poke responses in propofol-seeking behavior induced by conditioned cues was much higher compared to contextual cues. U0126 (5.0 μg/side, Lateral Ventricle (LV)) pretreatment significantly decreased the active responses induced by conditioned cues, which was associated with a large decline in the expression of p-ERK in the NAc. Moreover, microinjectionofU0126 (2.0 μg/side) in the NAc also attenuated the active responses of propofol-seeking behavior. Additionally, microinjections with U0126 in the LV (5.0 μg/side) or NAc (2.0 μg/side) both failed to alter sucrose self-administration or locomotor activity of rats. Therefore, we conclude that ERK phosphorylation in the NAc maybe involved in propofol relapse.
资助项目	NSFC [81771431]; WZKJ [Y20210126]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0091-3057
EISSN	1873-5177
卷号	219 页码:173447
DOI	10.1016/j.pbb.2022.173447
页数	8
WOS类目	Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS记录号	WOS:000848682900001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	35970339
SCOPUSEID	2-s2.0-85136454699
通讯作者地址	[Yang, Jianping]Department of Anesthesiology,The First Affiliated Hospital of Soochow University,188 Shi-Zi Street,Suzhou,215000,China
Scopus学科分类	Biochemistry;Toxicology;Pharmacology;Clinical Biochemistry;Biological Psychiatry;Behavioral Neuroscience
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/155444
专题	眼视光学院（生物医学工程学院）、附属眼视光医院附属第二医院_麻醉重点学科实验室
通讯作者	Yang, Jianping
作者单位	1.Department of Anesthesiology,The First Affiliated Hospital of Soochow University,188 Shi-Zi Street,Suzhou,215000,China; 2.Eye Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 3.Key Laboratory of Anesthesiology of Zhejiang Province and Department of Anesthesiology,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 4.Key Laboratory of Addiction Research of Zhejiang Province,Ningbo Kangning Hospital,School of Medicine,Ningbo University,Ningbo,315201,China; 5.Zhejiang Pharmaceutical College,Zhejiang Province,Ningbo,315100,China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院; 附属第二医院_麻醉重点学科实验室
推荐引用方式 GB/T 7714	Wang, Benfu,Yang, Xiaowei,Zhou, Wenhua,et al. Involvement of the ERK signaling pathways in the NAc in propofol-seeking behavior induced by cues in rats.[J]. Pharmacology, biochemistry, and behavior,2022,219:173447.
APA	Wang, Benfu, Yang, Xiaowei, Zhou, Wenhua, Zhu, Huaqiang, Lian, Qingquan, & Yang, Jianping. (2022). Involvement of the ERK signaling pathways in the NAc in propofol-seeking behavior induced by cues in rats.. Pharmacology, biochemistry, and behavior, 219, 173447.
MLA	Wang, Benfu,et al."Involvement of the ERK signaling pathways in the NAc in propofol-seeking behavior induced by cues in rats.".Pharmacology, biochemistry, and behavior 219(2022):173447.