ALB, HP, OAF and RBP4 as novel protein biomarkers for identifying cured patients with pulmonary tuberculosis by DIA.

doi:10.1016/j.cca.2022.08.002

科研成果详情

题名	ALB, HP, OAF and RBP4 as novel protein biomarkers for identifying cured patients with pulmonary tuberculosis by DIA.
作者	Lu, Qiqi 1; Liu, Jun 1; Yu, Yi 1,2; Liang, Hong-Feng 2; Zhang, Shan-Qiang 1; Li, Zhi-Bin 1,2,4; Chen, Jia-Xi3,4; Xu, Qiu-Gui 2; Li, Ji-Cheng 1,2,4
发表日期	2022-10-01
发表期刊	Clinica chimica acta international journal of clinical chemistry 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Data-independent acquisition Directly observed treatment short-course Protein biomarkers Proteomics Pulmonary tuberculosis
其他关键词	IDENTIFICATION ; MECHANISMS ; RISK
摘要	Pulmonary tuberculosis (TB) is a serious infectious disease that lacks robust blood-based biomarkers to identify cured TB. Some discharged patients are not fully cured and may relapse or even develop multidrug-resistant TB. This study is committed to finding proteomic-based plasma biomarkers to support establishing laboratory standards for clinical TB cure., Data-independent acquisition (DIA) was used to obtain the plasma protein expression profiles of TB patients at different treatment stages compared with healthy controls. Multivariate statistical methods and bioinformatics were used to analyze the data., Bioinformatic analysis suggests coagulation dysfunction and vitamin and lipid metabolism disturbances in TB. Albumin (ALB), haptoglobin (HP), out at first protein homolog (OAF), and retinol-binding protein 4 (RBP4) can be used to establish a diagnostic model for the efficacy evaluation of TB with an area under the curve of 0.963, which could effectively distinguish untreated TB patients from cured patients., Our research demonstrated that ALB, HP, OAF and RBP4 can be potential biomarkers for evaluating the efficacy of TB. These findings may provide experimental data for establishing the laboratory indicators of clinical TB cure and providing clinicians with new targets for exploring the underlying mechanisms of TB pathogenesis.
资助项目	National Natural Science Foundation of China [81772266]; Natural Science Foundation of Guangdong Province [2017A030311014]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0009-8981
EISSN	1873-3492
卷号	535 页码:82-91
DOI	10.1016/j.cca.2022.08.002
页数	10
WOS类目	Medical Laboratory Technology
WOS研究方向	Medical Laboratory Technology
WOS记录号	WOS:000860648400001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	35964702
SCOPUSEID	2-s2.0-85136484835
通讯作者地址	[Li, Ji-Cheng]Institute of Cell Biology,Zhejiang University School of Medicine,Hangzhou,310058,China
Scopus学科分类	Biochemistry;Clinical Biochemistry;Biochemistry (medical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/155441
专题	其他_附属台州医院（浙江省台州医院）
通讯作者	Li, Ji-Cheng
作者单位	1.The Medical Research Center,Yue Bei People's Hospital,Shantou University Medical College,Shaoguan,512025,China; 2.The Central Laboratory,Yangjiang People's Hospital,Yangjiang,529500,China; 3.Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Taizhou,318050,China; 4.Institute of Cell Biology,Zhejiang University School of Medicine,Hangzhou,310058,China
推荐引用方式 GB/T 7714	Lu, Qiqi,Liu, Jun,Yu, Yi,et al. ALB, HP, OAF and RBP4 as novel protein biomarkers for identifying cured patients with pulmonary tuberculosis by DIA.[J]. Clinica chimica acta international journal of clinical chemistry,2022,535:82-91.
APA	Lu, Qiqi., Liu, Jun., Yu, Yi., Liang, Hong-Feng., Zhang, Shan-Qiang., ... & Li, Ji-Cheng. (2022). ALB, HP, OAF and RBP4 as novel protein biomarkers for identifying cured patients with pulmonary tuberculosis by DIA.. Clinica chimica acta international journal of clinical chemistry, 535, 82-91.
MLA	Lu, Qiqi,et al."ALB, HP, OAF and RBP4 as novel protein biomarkers for identifying cured patients with pulmonary tuberculosis by DIA.".Clinica chimica acta international journal of clinical chemistry 535(2022):82-91.