Alpha-mangostin Suppresses Receptor Activator Nuclear Factor-kappa B Ligand-induced Osteoclast Formation and Bone Resorption in RAW264.7 Cells by Inhibiting the Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase Signaling

doi:10.4103/pm.pm_203_17

科研成果详情

题名	Alpha-mangostin Suppresses Receptor Activator Nuclear Factor-kappa B Ligand-induced Osteoclast Formation and Bone Resorption in RAW264.7 Cells by Inhibiting the Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase Signaling
作者	Hong, Rong-Hua 1,2; Liang, Yi-Min 1,2; Pan, Han-Song 1,2; Cheng, Zhao-Hui 1,2; Li, Yong-Hua 1,2
发表日期	2018-07
发表期刊	PHARMACOGNOSY MAGAZINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Alpha-mangostin c-Jun N-terminal kinase extracellular signal-regulated kinase osteoclast
其他关键词	IN-VITRO ; DIFFERENTIATION ; MACROPHAGES ; APOPTOSIS ; MARROW ; CANCER
摘要	Background: Excessive osteoclast formation and over-activated function lead to a series of osteoclast-related diseases. Suppression of osteoclastogenesis is likely to be an effective means for the treatment of these diseases. Objective: In this study, we investigated the effects of alpha-mangostin (alpha-MAG), a natural compound derived from Garcinia mangostana, on osteoclast formation and function in RAW264.7 cells. Materials and Methods: Different concentrations of alpha-MAG were used to explore its effects on receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and further, we investigated the mechanism by Western Blotting. Results: The study revealed that alpha-MAG attenuated RANKL-induced osteoclastogenesis. Moreover, the effects were confirmed to be caused by the suppression of the phosphorylation of the extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling and this inhibitory effect could be rescued by the administration of the JNK and p38 agonist anisomycin. Conclusion: The study results demonstrated that alpha-MAG could impair RANKL-induced osteoclastogenesis by inhibiting the ERK and JNK signaling pathways in RAW264.7 cells.
资助项目	Zhejiang Medical and Health Science and Technology Program [2017KY715]; Zhejiang Natural Sicense Fund [LY18H060005]
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
出版地	MUMBAI
ISSN	0973-1296
EISSN	0976-4062
卷号	14 期号:56 页码:390-396
DOI	10.4103/pm.pm_203_17
页数	7
WOS类目	Chemistry, Medicinal
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000442526900018
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85052333446
通讯作者地址	[Li, Yong-Hua]Department of Orthopedic Surgery,Huangyan Hospital,Wenzhou Medical University,Wenzhou Medical College,Huangyan, Taizhou, Zhejiang,318020,China
Scopus学科分类	Pharmaceutical Science;Drug Discovery
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15540
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_整形外科
通讯作者	Li, Yong-Hua
作者单位	1.Department of Orthopedic Surgery,Huangyan Hospital,Wenzhou Medical University,Wenzhou Medical College,Huangyan, Taizhou, Zhejiang,318020,China; 2.Department of Orthopedic Surgery,Taizhou First People's Hospital,Huangyan, Taizhou, Zhejiang,318020,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学_整形外科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学_整形外科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学_整形外科
推荐引用方式 GB/T 7714	Hong, Rong-Hua,Liang, Yi-Min,Pan, Han-Song,et al. Alpha-mangostin Suppresses Receptor Activator Nuclear Factor-kappa B Ligand-induced Osteoclast Formation and Bone Resorption in RAW264.7 Cells by Inhibiting the Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase Signaling[J]. PHARMACOGNOSY MAGAZINE,2018,14(56):390-396.
APA	Hong, Rong-Hua, Liang, Yi-Min, Pan, Han-Song, Cheng, Zhao-Hui, & Li, Yong-Hua. (2018). Alpha-mangostin Suppresses Receptor Activator Nuclear Factor-kappa B Ligand-induced Osteoclast Formation and Bone Resorption in RAW264.7 Cells by Inhibiting the Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase Signaling. PHARMACOGNOSY MAGAZINE, 14(56), 390-396.
MLA	Hong, Rong-Hua,et al."Alpha-mangostin Suppresses Receptor Activator Nuclear Factor-kappa B Ligand-induced Osteoclast Formation and Bone Resorption in RAW264.7 Cells by Inhibiting the Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase Signaling".PHARMACOGNOSY MAGAZINE 14.56(2018):390-396.