Immune-Protective Formulations and Process Strategies for Improved Survival and Function of Transplanted Islets.

doi:10.3389/fimmu.2022.923241

科研成果详情

题名	Immune-Protective Formulations and Process Strategies for Improved Survival and Function of Transplanted Islets.
作者	Shi, Yannan1; Zhao, Ying-Zheng1; Jiang, Zhikai 2; Wang, Zeqing1; Wang, Qian 1; Kou, Longfa2; Yao, Qing1
发表日期	2022-07-12
发表期刊	Frontiers in immunology 影响因子和分区
语种	英语
原始文献类型	Review
关键词	biomaterials cell therapy immune reactions islet encapsulation islet transplantation
其他关键词	MEDIATED INFLAMMATORY REACTION ; REGULATORY T-CELLS ; BETA-CELLS ; ENCAPSULATION DEVICE ; ALLOGRAFT SURVIVAL ; CONTROLLED-RELEASE ; DIABETES-MELLITUS ; PANCREATIC-ISLETS ; DEXTRAN SULFATE ; GRAFT-SURVIVAL
摘要	Type 1 diabetes (T1D) is an autoimmune disease caused by the immune system attacking and destroying insulin-producing β cells in the pancreas. Islet transplantation is becoming one of the most promising therapies for T1D patients. However, its clinical use is limited by substantial cell loss after islet infusion, closely related to immune reactions, including instant blood-mediated inflammatory responses, oxidative stress, and direct autoimmune attack. Especially the grafted islets are not only exposed to allogeneic immune rejection after transplantation but are also subjected to an autoimmune process that caused the original disease. Due to the development and convergence of expertise in biomaterials, nanotechnology, and immunology, protective strategies are being investigated to address this issue, including exploring novel immune protective agents, encapsulating islets with biomaterials, and searching for alternative implantation sites, or co-transplantation with functional cells. These methods have significantly increased the survival rate and function of the transplanted islets. However, most studies are still limited to animal experiments and need further studies. In this review, we introduced the immunological challenges for islet graft and summarized the recent developments in immune-protective strategies to improve the outcomes of islet transplantation.
资助项目	Zhejiang Medical and Health Science and Technology Program[2022492641];National Natural Science Foundation of China[81903551];
出版者	FRONTIERS MEDIA SA
ISSN	1664-3224
卷号	13 页码:923241
DOI	10.3389/fimmu.2022.923241
页数	18
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:000831938000001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	35903090
SCOPUSEID	2-s2.0-85134962789
通讯作者地址	[Yao, Qing]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China ; [Kou, Longfa]The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Immunology and Allergy;Immunology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/155391
专题	药学院（分析测试中心）第二临床医学院、附属第二医院、育英儿童医院附属第二医院_妇产科
通讯作者	Kou, Longfa; Yao, Qing
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China; 2.The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）; 第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Shi, Yannan,Zhao, Ying-Zheng,Jiang, Zhikai,et al. Immune-Protective Formulations and Process Strategies for Improved Survival and Function of Transplanted Islets.[J]. Frontiers in immunology,2022,13:923241.
APA	Shi, Yannan., Zhao, Ying-Zheng., Jiang, Zhikai., Wang, Zeqing., Wang, Qian., ... & Yao, Qing. (2022). Immune-Protective Formulations and Process Strategies for Improved Survival and Function of Transplanted Islets.. Frontiers in immunology, 13, 923241.
MLA	Shi, Yannan,et al."Immune-Protective Formulations and Process Strategies for Improved Survival and Function of Transplanted Islets.".Frontiers in immunology 13(2022):923241.