Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.

doi:10.3724/abbs.2022068

科研成果详情

题名	Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.
作者	Zhang, Rui1; Liu, Shuanghui1; Gong, Bojiang1; Xie, Wenran1; Zhao, Youjuan1; Xu, Liang1; Zheng, Yi1; Jin, Shengnan1; Ding, Chunming1; Xu, Chang 2; Dong, Zhixiong1
发表日期	2022-07
发表期刊	Acta biochimica et biophysica Sinica 影响因子和分区
语种	英语
原始文献类型	Article
关键词	DNA damage response Kif4A apoptosis colorectal cancer neoadjuvant chemoradiotherapy
其他关键词	INTRACELLULAR TRAFFICKING ; CHROMOKINESIN KIF4A ; EXPRESSION ; SPINDLE ; BIOMARKER ; PHASE ; PRC1
摘要	{AbstractText=More and more patients with advanced colorectal cancer (CRC) have benefited from surgical resection or ablation following neoadjuvant chemoradiotherapy (nCRT), but nCRT may be ineffective and have potential risks to some patients. Therefore, it is necessary to discover effective biomarkers for predicting the nCRT efficacy in CRC patients. Chromokinesin Kif4A plays a critical role in mitosis, DNA damage repair and tumorigenesis, but its relationship with nCRT efficacy in advanced CRC remains unclear. Here, we find that Kif4A expression in pretreated tumor tissue is positively correlated with poorer tumor regression after receiving nCRT ( P=0.005). Knockdown of endogenous Kif4A causes an increased sensitivity of CRC cells to chemotherapeutic drugs 5-fluorouracil (5-FU) and Cisplatin (DDP), while overexpression of Kif4A enhances resistance of CRC cells to the chemotherapeutic drugs. Furthermore, depending on its motor domain and tail domain, Kif4A regulates DNA damage response (DDR) induced by 5-FU or DDP treatment in CRC cells. In conclusion, we demonstrate that Kif4A may be a potential independent biomarker for predicting the nCRT efficacy in advanced CRC patients, and Kif4A regulates chemosensitivity of CRC cells through controlling DDR.}
资助项目	Zhejiang Provincial Natural Science Foundation of China [LY21C070004]; Basic Research Project of Wenzhou Municipal Science and Technology Bureau [Y20190208]; High-Level Innovation Team of Universities in Zhejiang Province [604090352/610]; Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A) [437601607]
出版者	SCIENCE PRESS
出版地	BEIJING
ISSN	1672-9145
EISSN	1745-7270
卷号	54 期号:7 页码:1-12
DOI	10.3724/abbs.2022068
页数	12
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000856547000007
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	35882623
SCOPUSEID	2-s2.0-85135108861
通讯作者地址	[Ding, Chunming]Zhejiang Provincial Key Laboratory of Medical Genetics,Key Laboratory of Laboratory Medicine,Ministry of Education,School of Laboratory Medicine and Life Science,Wenzhou Medical University,Wenzhou,325000,China ; [Xu, Chang]Department of Colorectal Surgery,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Dong, Zhixiong]Zhejiang Provincial Key Laboratory of Medical Genetics,Key Laboratory of Laboratory Medicine,Ministry of Education,School of Laboratory Medicine and Life Science,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Biophysics;Biochemistry;Molecular Biology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/155382
专题	检验医学院（生命科学学院、生物学实验教学中心）附属第一医院_肛肠外科
通讯作者	Ding, Chunming; Xu, Chang; Dong, Zhixiong
作者单位	1.Zhejiang Provincial Key Laboratory of Medical Genetics,Key Laboratory of Laboratory Medicine,Ministry of Education,School of Laboratory Medicine and Life Science,Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Colorectal Surgery,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）
通讯作者单位	检验医学院（生命科学学院、生物学实验教学中心）; 附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）
推荐引用方式 GB/T 7714	Zhang, Rui,Liu, Shuanghui,Gong, Bojiang,et al. Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.[J]. Acta biochimica et biophysica Sinica,2022,54(7):1-12.
APA	Zhang, Rui., Liu, Shuanghui., Gong, Bojiang., Xie, Wenran., Zhao, Youjuan., ... & Dong, Zhixiong. (2022). Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.. Acta biochimica et biophysica Sinica, 54(7), 1-12.
MLA	Zhang, Rui,et al."Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.".Acta biochimica et biophysica Sinica 54.7(2022):1-12.