Comparison of Long-Term Use of Low Dose Rituximab and Mycophenolate Mofetil in Chinese Patients With Neuromyelitis Optica Spectrum Disorder.

doi:10.3389/fneur.2022.891064

科研成果详情

题名	Comparison of Long-Term Use of Low Dose Rituximab and Mycophenolate Mofetil in Chinese Patients With Neuromyelitis Optica Spectrum Disorder.
作者	Lin, Jie 1; Xue, Binbin2; Li, Jia 1; Zhu, Ruofan 1; Pan, Juyuan1; Chen, Zhibo1; Zhang, Xu1; Li, Xiang1; Xia, Junhui1
发表日期	2022-05-06
发表期刊	Frontiers in neurology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	EDSS annual relapse rate mycophenolate mofetil neuromyelitis optica spectrum disorder rituximab
摘要	Several studies have reported the efficacy and safety of rituximab (RTX) and mycophenolate mofetil (MMF) in neuromyelitis optica spectrum disorder (NMOSD). This study aimed to evaluate the efficacy and safety of long-term use of low-dose RTX and MMF in Chinese patients with NMOSD., We retrospectively reviewed data from patients with NMOSD in our hospital. The enrolled patients were administrated different immunosuppressive agents. We accessed annual relapse rate (ARR), neurological disability (Expanded Disability Status Scale, EDSS), time to the next relapse, and adverse events., {AbstractText=EDSS and ARR were both reduced after RTX and MMF treatment. Kaplan-Meier analysis indicated that patients treated with RTX had a longer time to next relapse compared other immunosuppressive agents before RTX (log-rank test: p < 0.001). Furthermore, we evaluated the change of EDSS and ARR in RTX and MMF, and patients treated with RTX showed a better reduction. Eleven relapses from seven patients in group RTX and 20 relapses from 14 patients in group MMF were reported during follow-up.}, Long-term using of low dose of RTX and MMF were effective and tolerable in Chinese patients with NMOSD. Compared with MMF, RTX showed a better way to reduce the ARR.
ISSN	1664-2295
卷号	13 页码:891064
DOI	10.3389/fneur.2022.891064
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35599732
SCOPUSEID	2-s2.0-85130684554
通讯作者地址	[Li, Xiang]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Xia, Junhui]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/155241
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院_麻醉科第一临床医学院（信息与工程学院）、附属第一医院_麻醉科
通讯作者	Li, Xiang; Xia, Junhui
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Lin, Jie,Xue, Binbin,Li, Jia,et al. Comparison of Long-Term Use of Low Dose Rituximab and Mycophenolate Mofetil in Chinese Patients With Neuromyelitis Optica Spectrum Disorder.[J]. Frontiers in neurology,2022,13:891064.
APA	Lin, Jie., Xue, Binbin., Li, Jia., Zhu, Ruofan., Pan, Juyuan., ... & Xia, Junhui. (2022). Comparison of Long-Term Use of Low Dose Rituximab and Mycophenolate Mofetil in Chinese Patients With Neuromyelitis Optica Spectrum Disorder.. Frontiers in neurology, 13, 891064.
MLA	Lin, Jie,et al."Comparison of Long-Term Use of Low Dose Rituximab and Mycophenolate Mofetil in Chinese Patients With Neuromyelitis Optica Spectrum Disorder.".Frontiers in neurology 13(2022):891064.