Fibroblast growth factor 1 attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease

科研成果详情

题名	Fibroblast growth factor 1 attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease
作者	Wei, Xiaojie1; He, Songbin 2; Wang, Zhouguang 3; Wu, Jiamin3; Zhang, Jinjing 3; Cheng, Yi 3; Yang, Jie 3; Xu, Xinlong1; Chen, Zaifeng1; Ye, Junmin 4; Chen, Li 4; Lin, Li3; Xiao, Jian3
发表日期	2014-12-31
发表期刊	AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	ER stress alpha-synuclein parkinson's disease FGF1
其他关键词	FIBROBLAST-GROWTH-FACTOR ; ENDOPLASMIC-RETICULUM STRESS ; UNFOLDED PROTEIN RESPONSE ; SPINAL-CORD-INJURY ; ALPHA-SYNUCLEIN ; OXIDATIVE INJURY ; SUBSTANTIA-NIGRA ; NEURONS ; DEATH ; ACTIVATION
摘要	Parkinson's disease (PD) is a degenerative disorder of the central nervous system and is characterized by motor system disorders resulting in loss of dopamine producing brain cells. Acidic fibroblast growth factor, also called FGF1, promotes the survival of neurons. The aims of the present study were to confirm FGF1 could protect neurons cultures from 6-hydroxydopamine (6-OHDA) toxicity in vitro and in vivo. Our results demonstrated FGF1 administration improved the motor function recovery, increased the TH-positive neurons survival and up-regulated the levels of neurotransmitters in PD rats. Meanwhile, FGF1 prevents the death of DA neuron at least in part by reducing the levels of alpha-synuclein and ER stress. The administration of FGF1 activated downstream signals PI3K/Akt and ERK1/2. In conclusion, FGF1 diminished a-synuclein neurotoxicity by down regulating ER stress mediators and the level of apoptosis, and these effects may underlying the activation of the PI3K/Akt and ERK1/2 signal pathway.
资助项目	National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [81372112, 81302775, 81260202]; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [Y2090834]; Zhejiang Provincial Project of Key Scientific Group [2012R10042]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1943-8141
卷号	6 期号:6 页码:664-677
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000348299700004
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-84912079075
通讯作者地址	[Xiao, Jian]School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Molecular Medicine;Clinical Biochemistry;Cancer Research
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15507
专题	温州医科大学其他_附属舟山医院（舟山医院）药学院（分析测试中心）_生物制药系_生物制药工程
通讯作者	Xiao, Jian
作者单位	1.Department of Neurosurgery, Cixi People’s Hospital, Wenzhou Medical University,Ningbo,315300,China; 2.Department of Neurology, Zhoushan Hospital, Wenzhou Medical University,Zhoushan,316000,China; 3.School of Pharmacy, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University,Wenzhou,325035,China; 4.Department of Anesthesia, The First Affliated Hospital, Gangnan Medical University,Ganzhou,341000,China
第一作者单位	温州医科大学
通讯作者单位	药学院（分析测试中心）_生物制药系_生物制药工程
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Wei, Xiaojie,He, Songbin,Wang, Zhouguang,et al. Fibroblast growth factor 1 attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2014,6(6):664-677.
APA	Wei, Xiaojie., He, Songbin., Wang, Zhouguang., Wu, Jiamin., Zhang, Jinjing., ... & Xiao, Jian. (2014). Fibroblast growth factor 1 attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 6(6), 664-677.
MLA	Wei, Xiaojie,et al."Fibroblast growth factor 1 attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 6.6(2014):664-677.