Efficacy of Curcumin for Wound Repair in Diabetic Rats/Mice: A Systematic Review and Meta-analysis of Preclinical Studies

doi:10.2174/1381612827666210617122026

科研成果详情

名称	Efficacy of Curcumin for Wound Repair in Diabetic Rats/Mice: A Systematic Review and Meta-analysis of Preclinical Studies
作者	Li, Yuan 1; Zhao, Sheng1; Van der Merwe, Leanne 2; Dai, Wentong 1; Lin, Cai1
发表期刊	CURRENT PHARMACEUTICAL DESIGN
语种	英语
原始文献类型	Review
关键词	Angiogenesis curcumin diabetic foot ulcers meta-analysis preclinical evidence wound healing systematic review
其他关键词	HEALING ACTIVITY ; FOOT ULCERS ; ANGIOGENESIS ; ANTIOXIDANT ; PREVALENCE
摘要	Background: Curcumin possesses multiple bioactivities that have beneficial effects on diabetic foot ulcers. Herein, we aimed to conduct a preclinical systematic review of 9 studies, including a total of 262 animals, to assess the possible mechanisms of curcumin for wound healing in diabetic animals. Methods: Five databases were searched from inception to May 12, 2020; Rev-Man 5.3 software was applied for data analyses. Cochrane Collaboration's tool 10-item checklist was used to evaluate the methodological quality, and data revealed scores of risk of bias ranging from 2 to 5. Results: Meta-analysis indicated that curcumin had significant effects on wound healing rate and blood vessel density when compared with control (P < 0.05). The wound regeneration properties of curcumin for diabetic wounds are thought to mainly work through the possible mechanisms of antioxidation, enhanced cell proliferation, increased collagen formation, and angiogenesis. However, the anti-inflammatory effect on wounds in diabetic animals remain controversial. Conclusion: The findings indicate that more randomized controlled trials should be pursued to obtain more reliable results regarding inflammatory response. Overall, curcumin might be a probable candidate for diabetic foot ulcers and may contribute to future clinical trials. Prospero Registration: CRD42020188981.
资助项目	Key Science and Technology Program of Zhejiang Province, China [2017C01054]; Key Science and Technology Program of Wenzhou, China [ZY2019003]
出版者	BENTHAM SCIENCE PUBL LTD
出版地	SHARJAH
ISSN	1381-6128
EISSN	1873-4286
卷号	28
期号	3
页码	186-196
DOI	10.2174/1381612827666210617122026
页数	11
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000737851000002
收录类别	SCIE
发布日期	2022
PubMed ID	34139977
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154868
专题	附属第一医院_烧伤科国际教育学院
通讯作者	Lin, Cai
作者单位	1.Wenzhou Med Univ, Dept Burn, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Sch Int Studies, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院_烧伤科
推荐引用方式 GB/T 7714	Li, Yuan,Zhao, Sheng,Van der Merwe, Leanne,et al. Efficacy of Curcumin for Wound Repair in Diabetic Rats/Mice: A Systematic Review and Meta-analysis of Preclinical Studies. 2022.