Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications

doi:10.3389/fbioe.2022.845735

科研成果详情

名称	Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications
作者	Cui, Rongwei 1; Zhang, Luhan 1,2; Ou, Rongying 3; Xu, Yunsheng 2; Xu, Lizhou 4,5; Zhan, Xiao-Yong 1; Li, Danyang 1
发表期刊	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
语种	英语
原始文献类型	Review
关键词	polysaccharide hydrogel wound dressing design considerations clinical applications physicochemical properties biological functionalities
其他关键词	GELATIN ; SCAFFOLDS ; SEAWEED
摘要	Wound management remains a worldwide challenge. It is undeniable that patients with problems such as difficulties in wound healing, metabolic disorder of the wound microenvironment and even severely infected wounds etc. always suffer great pain that affected their quality of lives. The selection of appropriate wound dressings is vital for the healing process. With the advances of technology, hydrogels dressings have been showing great potentials for the treatment of both acute wounds (e.g., burn injuries, hemorrhage, rupturing of internal organs/aorta) and chronic wounds such as diabetic foot and pressure ulcer. Particularly, in the past decade, polysaccharide-based hydrogels which are made up with abundant and reproducible natural materials that are biocompatible and biodegradable present unique features and huge flexibilities for modifications as wound dressings and are widely applicable in clinical practices. They share not only common characteristics of hydrogels such as excellent tissue adhesion, swelling, water absorption, etc., but also other properties (e.g., anti-inflammatory, bactericidal and immune regulation), to accelerate wound re-epithelialization, mimic skin structure and induce skin regeneration. Herein, in this review, we highlighted the importance of tailoring the physicochemical performance and biological functions of polysaccharide-based hydrogel wound dressings. We also summarized and discussed their clinical states of, aiming to provide valuable hints and references for the future development of more intelligent and multifunctional wound dressings of polysaccharide hydrogels.
资助项目	National Natural Science Foundation of China [52103198, 31870001, 81771531, 81871129, 82072862, 82072863, ZSQYBRJH0019]; Shenzhen Science and Technology Innovation Commission Fund [JCYJ20210324122802006]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2296-4185
卷号	10
DOI	10.3389/fbioe.2022.845735
页数	8
WOS类目	Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS记录号	WOS:000772878000001
收录类别	SCIE
发布日期	2022-03-07
PubMed ID	35321022
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154818
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
通讯作者	Zhan, Xiao-Yong
作者单位	1.Sun Yat sen Univ, Affiliated Hosp 7, Res Ctr, Shenzhen, Peoples R China; 2.Sun Yat sen Univ, Affiliated Hosp 7, Dept Dermatovenereol, Shenzhen, Peoples R China; 3.Wenzhou Med Univ, Dept Gynaecol & Obstet, Affiliated Hosp 1, Wenzhou, Peoples R China; 4.ZJU Hangzhou Global Sci & Technol Innovat Ctr, Hangzhou, Peoples R China; 5.Imperial Coll London, Dept Mat, London, England
推荐引用方式 GB/T 7714	Cui, Rongwei,Zhang, Luhan,Ou, Rongying,et al. Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications. 2022.