Gut Microbiota - A Potential Contributor in the Pathogenesis of Bipolar Disorder

doi:10.3389/fnins.2022.830748

科研成果详情

名称	Gut Microbiota - A Potential Contributor in the Pathogenesis of Bipolar Disorder
作者	Zhang, Peifen 1,2; Kong, Lingzhuo 1; Huang, Huimin 3; Pan, Yanmeng 1; Zhang, Danhua 1; Jiang, Jiajun 1; Shen, Yuting3; Xi, Caixi 1; Lai, Jianbo 1,2,4,5; Ng, Chee H.6,7; Hu, Shaohua 1,2,4,5
发表期刊	FRONTIERS IN NEUROSCIENCE
语种	英语
原始文献类型	Review
关键词	bipolar disorder gut microbiota gut-brain axis pathogenesis treatment
其他关键词	INFLAMMATORY-BOWEL-DISEASE ; BODY HABITATS ; FATTY-ACIDS ; DEPRESSION ; DOPAMINE ; HEALTH ; EXPRESSION ; MICROGLIA ; SEROTONIN ; BEHAVIOR
摘要	Bipolar disorder (BD) is one of the major psychiatric disorders that is characterized by recurrent episodes of depression and mania (or hypomania), leading to seriously adverse outcomes with unclear pathogenesis. There is an underlying relationship between bacterial communities residing in the gut and brain function, which together form the gut-brain axis (GBA). Recent studies have shown that changes in the gut microbiota have been observed in a large number of BD patients, so the axis may play a role in the pathogenesis of BD. This review summarizes briefly the relationship between the GBA and brain function, the composition and changes of gut microbiota in patients with BD, and further explores the potential role of GBA-related pathway in the pathogenesis of BD as well as the limitations in this field at present in order to provide new ideas for the future etiology research and drug development.
资助项目	National Natural Science Foundation of China [81971271]; Zhejiang Provincial Key Research and Development Program [2021C03107]; Zhejiang Provincial Natural Science Foundation [LQ20H090013]; Program from the Health and Family Planning Commission of Zhejiang Province [2020KY548]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
EISSN	1662-453X
卷号	16
DOI	10.3389/fnins.2022.830748
页数	13
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000781416800001
收录类别	SCIE ; SSCI
发布日期	2022-03-23
PubMed ID	35401095
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154801
专题	精神医学学院_精神医学系
通讯作者	Hu, Shaohua
作者单位	1.Zhejiang Univ, Affiliated Hosp 1, Dept Psychiat, Sch Med, Hangzhou, Peoples R China; 2.Zhejiang Univ, MOE Frontier Sci Ctr Brain Sci & Brain Machine In, Hangzhou, Peoples R China; 3.Wenzhou Med Univ, Dept Psychiat, Wenzhou, Peoples R China; 4.Key Lab Mental Disorder Management Zhejiang Prov, Hangzhou, Peoples R China; 5.Zhejiang Univ, Brain Res Inst, Hangzhou, Peoples R China; 6.Melbourne Clin, Dept Psychiat, Richmond, Vic, Australia; 7.Univ Melbourne, St Vincents Hosp, Richmond, Vic, Australia
推荐引用方式 GB/T 7714	Zhang, Peifen,Kong, Lingzhuo,Huang, Huimin,et al. Gut Microbiota - A Potential Contributor in the Pathogenesis of Bipolar Disorder. 2022.