Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA

doi:10.3389/fpsyt.2022.779239

科研成果详情

名称	Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA
作者	Li, HuiLing1; Zhao, Dong 1; Liu, YuQing1; Xv, JingWen 1; Huang, HanZhi 1; Jin, Yutong 1; Lu, Yiying 4; Qi, YuanYuan 3; Zhou, Qiang1,2
发表期刊	FRONTIERS IN PSYCHIATRY
语种	英语
原始文献类型	Review
关键词	neuroimaging cue-reactivity tobacco alcohol drug
其他关键词	BRAIN ACTIVATION ; FUNCTIONAL CONNECTIVITY ; POSTERIOR CINGULATE ; PREFRONTAL CORTEX ; METHADONE-MAINTENANCE ; SMOKING-CESSATION ; CIGARETTE-SMOKING ; HEROIN-ADDICTS ; SELF-EFFICACY ; COCAINE
摘要	Abuses of most illegal drugs, including methamphetamine, marijuana, cocaine, heroin, and polydrug, are usually in conjunction with alcohol and tobacco. There are similarities and associations between the behavior, gene, and neurophysiology of such abusers, but the neural overlaps of their cue-reactivity and the correlation of neural overlap with drug craving still needs to be further explored. In this study, an Activation Likelihood Estimation (ALE) was performed on brain activation under legal (tobacco, alcohol) and illegal drug cues, for identifying the similarities in brain functions between different craving states. A Comprehensive meta-analysis (CMA) on the correlation coefficient between brain activation and craving scores in the selected literatures with subjective craving reports explained the degree of the craving via brain imaging results. In ALE, co-activation areas of the three cue-reactivity (posterior cingulate, caudate, and thalamus) suggest that the three cue-reactivity may all arouse drug-use identity which is a predictor of relapse and generation of conditioned reflexes under reward memory, thus leading to illegal drug relapses. In CMA, the brain activation was significantly correlated with subjective craving, with a correlation coefficient of 0.222. The neural overlap of tobacco, alcohol and most of the prevalent illegal drug cues not only further helps us understand the neural mechanism of substance co-abuse and relapse, but also provides implications to detoxification. Furthermore, the correlation between brain activation and craving is low, suggesting the accuracy of craving-based quantitative evaluation by neuroimaging remains unclear.
资助项目	National Social Science Foundation of China [20BSH047]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-0640
卷号	13
DOI	10.3389/fpsyt.2022.779239
页数	16
WOS类目	Psychiatry
WOS研究方向	Psychiatry
WOS记录号	WOS:000789852300001
收录类别	SCIE ; SSCI
发布日期	2022-04-06
PubMed ID	35463497
社科自定义期刊分类	E类
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154778
专题	精神医学学院_心理学系其他_附属康宁医院（温州市康宁医院）
通讯作者	Zhou, Qiang
作者单位	1.Wenzhou Med Univ, Dept Psychol, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Peoples R China; 3.Zhejiang Moganshan Female Drug Detoxificat Ctr, Huzhou, Peoples R China; 4.Lingnan Normal Univ, Mental Hlth Educ & Counseling Ctr, Zhanjiang, Peoples R China
第一作者单位	精神医学学院_心理学系
推荐引用方式 GB/T 7714	Li, HuiLing,Zhao, Dong,Liu, YuQing,et al. Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA. 2022.