Cancer-associated fibroblasts in breast cancer: Challenges and opportunities

doi:10.1002/cac2.12291

科研成果详情

名称	Cancer-associated fibroblasts in breast cancer: Challenges and opportunities
作者	Hu, Dengdi 1; Li, Zhaoqing 2,3,4; Zheng, Bin 1; Lin, Xixi 2,3,4; Pan, Yuehong1; Gong, Peirong 1; Zhuo, Wenying 1,2,3,4; Hu, Yujie 1; Chen, Cong 2,3,4; Chen, Lini 2,3,4; Zhou, Jichun 2,3,4; Wang, Linbo 2,3,4
发表期刊	CANCER COMMUNICATIONS
语种	英语
原始文献类型	Review
关键词	Cancer-associated fibroblasts breast cancer therapeutic target tumor microenvironment biomarker tumor heterogeneity
其他关键词	NERVE GROWTH-FACTOR ; EPITHELIAL-MESENCHYMAL TRANSITION ; INVASIVE DUCTAL CARCINOMA ; PANCREATIC STELLATE CELLS ; PROMOTES TUMOR-GROWTH ; PHASE-II TRIAL ; ACTIVATION PROTEIN ; TGF-BETA ; STROMAL FIBROBLASTS ; PODOPLANIN EXPRESSION
摘要	The tumor microenvironment is proposed to contribute substantially to the progression of cancers, including breast cancer. Cancer-associated fibroblasts (CAFs) are the most abundant components of the tumor microenvironment. Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors, generating exosomes, releasing nutrients, reshaping the extracellular matrix, and suppressing the function of immune cells. CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers. Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials. Here, we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer. We hope that summarizing CAF-related studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer.
资助项目	National Natural Science Foundation of China [81602471, 81672729, 81972453, 81972597]; Natural Science Foundation of Zhejiang Province [LY19H160055, LY19H160059, LR22H160011]; Natural Science Foundation of Ningbo [2019A610315]; Cixi Agricultural and Social Development Science and Technology Project [CN2020006]; Zheng Shu Medical Elite Scholarship Fund
出版者	WILEY
出版地	HOBOKEN
EISSN	2523-3548
卷号	42
期号	5
页码	401-434
DOI	10.1002/cac2.12291
页数	34
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000794179000001
收录类别	SCIE
发布日期	2022-05-01
Pubmed记录号	35481621
ESI热点论文	2024-05
ESI高被引论文	2024-05
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154759
专题	其他_附属慈溪医院（慈溪市人民医院）
通讯作者	Zhou, Jichun
作者单位	1.Wenzhou Med Univ, Affiliated Cixi Hosp, Ningbo 315300, Zhejiang, Peoples R China; 2.Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Sch Med, Key Lab Canc Prevent & Intervent,Minist Educ, Hangzhou 310016, Zhejiang, Peoples R China; 3.Biomed Res Ctr, Hangzhou 310016, Zhejiang, Peoples R China; 4.Key Lab Biotherapy Zhejiang Prov, 3 Eastern Qingchun Rd, Hangzhou 310016, Zhejiang, Peoples R China
第一作者单位	附属慈溪医院（慈溪市人民医院）
推荐引用方式 GB/T 7714	Hu, Dengdi,Li, Zhaoqing,Zheng, Bin,et al. Cancer-associated fibroblasts in breast cancer: Challenges and opportunities. 2022.