Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges

doi:10.1016/j.tig.2022.01.005

科研成果详情

名称	Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges
作者	Wang, Congying 1; Wu, Wei 2,3; Yang, Haiyan1; Ye, Zhenhong 4,5,6,7; Zhao, Yue 4,5,6,7; Liu, Jun 8; Mu, Liangshan 2,3
发表期刊	TRENDS IN GENETICS
语种	英语
原始文献类型	Review
其他关键词	POLYCYSTIC-OVARY-SYNDROME ; GENOME-WIDE ASSOCIATION ; ANTI-MULLERIAN HORMONE ; BREAST-CANCER ; SUSCEPTIBILITY LOCI ; INSULIN-RESISTANCE ; BINDING GLOBULIN ; LUNG-FUNCTION ; RISK ; WOMEN
摘要	Identifying etiological risk factors is significant for preventing and treating patients with polycystic ovary syndrome (PCOS). Through genetic variation, Mendelian randomization (MR) assesses causal associations between PCOS risk and related exposure factors. This emerging technology has provided evidence of causal associations of anti-Mullerian hormone (AMH) levels, sex hormone-binding globulin (SHBG) levels, menopause age, adiposity, insulin resistance (IR), depression, breast cancer, ovarian cancer, obsessive-compulsive disorder (OCD), and forced vital capacity (FVC) with PCOS, while lacking associa-tions of type 2 diabetes mellitus (T2DM), coronary heart disease (CHD), stroke, anxiety disorder (AD), schizophrenia (SCZ), bipolar disorder (BIP), and offspring birth weight with PCOS. In this review, we briefly introduce the concept and methodology of MR in terms of the opportunities and challenges in this field based on recent results obtained from MR analyses involving PCOS.
资助项目	National Natural Science Foundation of China [82001503]; China Postdoctoral Science Foundation [2021T140600, 2020M671760]; National Key Research and Development Project of China [2021YFC2700402]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-001]
出版者	ELSEVIER SCIENCE LONDON
出版地	LONDON
ISSN	0168-9525
EISSN	1362-4555
卷号	38
期号	5
页码	468-482
DOI	10.1016/j.tig.2022.01.005
页数	15
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:000793468000008
收录类别	SCIE
发布日期	2022-05-01
PubMed ID	35094873
自定义期刊分类	T3(B)类
TOP期刊	TOP期刊
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154746
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心
通讯作者	Mu, Liangshan
作者单位	1.Wenzhou Med Univ, Reprod Med Ctr, Affiliated Hosp 1, 96 Fuxue Rd, Wenzhou 325000, Peoples R China; 2.Zhejiang Univ, Sch Med, Womens Hosp, Key Lab Reprod Genet,Minist Educ, Hangzhou 310006, Zhejiang, Peoples R China; 3.Zhejiang Univ, Sch Med, Womens Hosp, Dept Reprod Endocrinol, Hangzhou 310006, Zhejiang, Peoples R China; 4.Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China; 5.Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China; 6.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China; 7.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China; 8.Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心
推荐引用方式 GB/T 7714	Wang, Congying,Wu, Wei,Yang, Haiyan,et al. Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges. 2022.