TIGIT as a Promising Therapeutic Target in Autoimmune Diseases

doi:10.3389/fimmu.2022.911919

科研成果详情

名称	TIGIT as a Promising Therapeutic Target in Autoimmune Diseases
作者	Yue, Chenran1; Gao, Sheng 2; Li, Shuting 3; Xing, Zhouhang1; Qian, Hengrong 3; Hu, Ying3; Wang, Wenqian4,5; Hua, Chunyan1
发表期刊	FRONTIERS IN IMMUNOLOGY
语种	英语
原始文献类型	Review
关键词	autoimmunity TIGIT immune regulation therapeutic target co-inhibitory receptors
其他关键词	REGULATORY T-CELLS ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; CUTTING EDGE ; B-CELLS ; RECEPTOR ; PATHOGENESIS ; MECHANISMS ; EXPRESSION ; IMMUNOGLOBULIN ; POLIOVIRUS
摘要	Co-inhibitory receptors (IRs) are molecules that protect host against autoimmune reactions and maintain peripheral self-tolerance, playing an essential role in maintaining immune homeostasis. In view of the substantial clinical progresses of negative immune checkpoint blockade in cancer treatment, the role of IRs in autoimmune diseases is also obvious. Several advances highlighted the substantial impacts of T cell immunoglobulin and ITIM domain (TIGIT), a novel IR, in autoimmunity. Blockade of TIGIT pathway exacerbates multiple autoimmune diseases, whereas enhancement of TIGIT function has been shown to alleviate autoimmune settings in mice. These data suggested that TIGIT pathway can be manipulated to achieve durable tolerance to treat autoimmune disorders. In this review, we provide an overview of characteristics of TIGIT and its role in autoimmunity. We then discuss recent approaches and future directions to leverage our knowledge of TIGIT as therapeutic target in autoimmune diseases.
资助项目	National Natural Science Foundation of China [81901660, 81802963]; China Scholarship Council [201808330646]; Zhejiang Medical Science Foundation [2018KY531]; Clinical Translation Academician Workstation Research Fund [18331215]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-3224
卷号	13
DOI	10.3389/fimmu.2022.911919
页数	18
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:000812852000001
收录类别	SCIE
发布日期	2022-06-03
PubMed ID	35720417
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154695
专题	基础医学院（机能实验教学中心）附属第二医院第二临床医学院，附属第二医院、育英儿童医院仁济学院_实验动物中心
通讯作者	Hua, Chunyan
作者单位	1.Wenzhou Med Univ, Sch Basic Med Sci, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Lab Anim Ctr, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Sch Clin Med Sci 2, Wenzhou, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 2, Dept Surg, Wenzhou, Peoples R China; 5.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China
第一作者单位	基础医学院（机能实验教学中心）
推荐引用方式 GB/T 7714	Yue, Chenran,Gao, Sheng,Li, Shuting,et al. TIGIT as a Promising Therapeutic Target in Autoimmune Diseases. 2022.