The Nuclear Translocation of Heme Oxygenase-1 in Human Diseases

doi:10.3389/fcell.2022.890186

科研成果详情

名称	The Nuclear Translocation of Heme Oxygenase-1 in Human Diseases
作者	Yang, Qing1,2; Wang, Wenqian2,3
发表期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
语种	英语
原始文献类型	Review
关键词	heme oxygenase-1 nuclear translocation noncanonical function tumorigenesis inflammation anticancer therapy
其他关键词	BROWN ADIPOSE-TISSUE ; NF-E2-RELATED FACTOR-2 NRF2 ; ENDOTHELIAL GROWTH-FACTOR ; PROSTATE-CANCER CELLS ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; UP-REGULATION ; ANDROGEN RECEPTOR ; TUMOR-GROWTH ; TRANSGLUTAMINASE ACTIVITY
摘要	Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in the degradation of heme to generate carbon monoxide (CO), free iron and biliverdin, which could then be converted to bilirubin by biliverdin reductase. HO-1 exhibits cytoprotective effects of anti-apoptosis, anti-oxidation, and anti-inflammation via these byproducts generated during the above process. In the last few years, despite the canonical function of HO-1 and possible biological significance of its byproducts, a noncanonical function, through which HO-1 exhibits functions in diseases independent of its enzyme activity, also has been reported. In this review, the noncanonical functions of HO-1 and its translocation in other subcellular compartments are summarized. More importantly, we emphasize the critical role of HO-1 nuclear translocation in human diseases. Intriguingly, this translocation was linked to tumorigenesis and tumor progression in lung, prostate, head, and neck squamous cell carcinomas and chronic myeloid leukemia. Given the importance of HO-1 nuclear translocation in human diseases, nuclear HO-1 as a novel target might be attractive for the prevention and treatment of human diseases.
资助项目	National Natural Science Foundation of China [81802963]; Basic Scientific Research Project of Wenzhou [2020Y0576]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2296-634X
卷号	10
DOI	10.3389/fcell.2022.890186
页数	12
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
WOS记录号	WOS:000826832800001
收录类别	SCIE
发布日期	2022-06-29
PubMed ID	35846361
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154671
专题	附属第二医院_乳腺外科附属第二医院第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Wang, Wenqian
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Breast Surg, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Plast Surg, Wenzhou, Peoples R China
第一作者单位	附属第二医院_乳腺外科; 第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Yang, Qing,Wang, Wenqian. The Nuclear Translocation of Heme Oxygenase-1 in Human Diseases. 2022.